Gstm5 glutathione S-transferase, mu 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gstm5provided by MGI
Official Full Name: glutathione S-transferase, mu 5provided by MGI
Primary source: MGI:MGI:1309466
See related: Ensembl:ENSMUSG00000004032 AllianceGenome:MGI:1309466
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fsc2
Summary: Enables glutathione transferase activity and identical protein binding activity. Predicted to be involved in several processes, including cellular detoxification of nitrogen compound; glutathione metabolic process; and nitrobenzene metabolic process. Located in cytosol and sperm fibrous sheath. Is expressed in several structures, including alimentary system; central nervous system; cranium; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; cystic fibrosis; larynx cancer; multiple sclerosis; and osteosarcoma. Orthologous to human GSTM3 (glutathione S-transferase mu 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 1126.9), cortex adult (RPKM 99.9) and 5 other tissues See more
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Genomic context

Location:: 3 F2.3; 3 46.83 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (107803240..107806002)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (107895854..107898685)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HK1S is tethered in the principal piece region by PFKMS, which in turn is bound tightly to GSTM5 in the fibrous sheath of spermatozoa.
Title: Molecular complex of three testis-specific isozymes associated with the mouse sperm fibrous sheath: hexokinase 1, phosphofructokinase M, and glutathione S-transferase mu class 5.
Data show that the primary transcription start site for mGstm5 is upstream of a TATA box in testis and downstream of this motif in somatic cells, and that the 5' flanking sequence of mGstm5 imparts germ cell-specific transcription.
Title: The proximal promoter governs germ cell-specific expression of the mouse glutathione transferase mGstm5 gene.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U24428 (e-PCR)
- UniSTS:163328

Gstm5 (e-PCR), detects polymorphism
- UniSTS:527378

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables glutathione binding	IEA Inferred from Electronic Annotation more info
enables glutathione binding	ISO Inferred from Sequence Orthology more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular detoxification of nitrogen compound	IEA Inferred from Electronic Annotation more info
involved_in cellular detoxification of nitrogen compound	ISO Inferred from Sequence Orthology more info
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glutathione metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in nitrobenzene metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nitrobenzene metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic catabolic process	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in sperm fibrous sheath	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glutathione S-transferase Mu 5

Names: GST class-mu 5; fibrous sheath component 2

NP_034490.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010360.3 → NP_034490.1 glutathione S-transferase Mu 5

See identical proteins and their annotated locations for NP_034490.1

Status: VALIDATED

Source sequence(s)

AC079042

Consensus CDS

CCDS17741.1

UniProtKB/Swiss-Prot

P48774, Q545W5

UniProtKB/TrEMBL

E9PVM7

Related

ENSMUSP00000004134.5, ENSMUST00000004134.11

Conserved Domains (3) summary

cd03209
Location:95 → 215

GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases

COG0625
Location:6 → 210

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

cd03075
Location:6 → 87

GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...