Pcdhb8 protocadherin beta 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pcdhb8provided by MGI
Official Full Name: protocadherin beta 8provided by MGI
Primary source: MGI:MGI:2136742
See related: Ensembl:ENSMUSG00000045876 AllianceGenome:MGI:2136742
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PcdhbH; Pcdhb5C
Summary: Enables calcium ion binding activity and identical protein binding activity. Predicted to be involved in cell adhesion. Predicted to be active in plasma membrane. Is expressed in several structures, including liver; nervous system; placenta; retina; and spleen. Orthologous to human PCDHB5 (protocadherin beta 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 18 B3; 18 19.47 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (37488324..37490663)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (37355271..37357610)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

Pcdhb8 (e-PCR), detects polymorphism
- UniSTS:515922

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protocadherin beta-8

Names: PCDH-beta-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053133.1 → NP_444363.1 protocadherin beta-8 precursor

See identical proteins and their annotated locations for NP_444363.1

Status: PROVISIONAL

Source sequence(s)

AY013790

Consensus CDS

CCDS29175.1

UniProtKB/Swiss-Prot

Q91XZ2

UniProtKB/TrEMBL

A8E4K7

Related

ENSMUSP00000054371.2, ENSMUST00000051163.3

Conserved Domains (3) summary

cd11304
Location:247 → 342

Cadherin_repeat; Cadherin tandem repeat domain

pfam08266
Location:31 → 112

Cadherin_2; Cadherin-like

pfam16492
Location:686 → 766

Cadherin_C_2; Cadherin cytoplasmic C-terminal