Nav3 neuron navigator 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nav3provided by MGI
Official Full Name: neuron navigator 3provided by MGI
Primary source: MGI:MGI:2183703
See related: Ensembl:ENSMUSG00000020181 AllianceGenome:MGI:2183703
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: POMFIL1; unc53H3; Pomfil1p; mKIAA0938; 4732483H20Rik; 9630020C08Rik
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including negative regulation of cell migration; negative regulation of interleukin-2 production; and regulation of microtubule polymerization or depolymerization. Located in nuclear envelope. Is expressed in central nervous system; liver; lung; notochord; and retina layer. Human ortholog(s) of this gene implicated in opiate dependence. Orthologous to human NAV3 (neuron navigator 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E18 (RPKM 6.2), cortex adult (RPKM 6.1) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D1; 10 57.18 cM

Exon count:: 45

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (109517121..110292148, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (109681260..110455722, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variants of NAV3, a neuronal morphogenesis protein, cause intellectual disability, developmental delay, and microcephaly.
Title: Variants of NAV3, a neuronal morphogenesis protein, cause intellectual disability, developmental delay, and microcephaly.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D19S653E (e-PCR)
- UniSTS:150568

NoName (e-PCR)
- UniSTS:236455

D12S1376E (e-PCR)
- UniSTS:153777

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
colocalizes_with microtubule end	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear outer membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neuron navigator 3

Names: pore membrane and/or filament-interacting-like protein 1; steerin 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081035.2 → NP_001074504.1 neuron navigator 3 isoform 1

Status: VALIDATED

Source sequence(s)

AC100120, AC122011, AC129336

Consensus CDS

CCDS36054.1

UniProtKB/TrEMBL

E9QMF5

Related

ENSMUSP00000032719.8, ENSMUST00000032719.15

Conserved Domains (5) summary

cd00009
Location:2033 → 2113

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

smart00382
Location:2030 → 2150

AAA; ATPases associated with a variety of cellular activities

cd00014
Location:81 → 182

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

pfam15898
Location:1775 → 1838

PRKG1_interact; cGMP-dependent protein kinase interacting domain

cl21455
Location:2017 → 2047

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001368815.1 → NP_001355744.1 neuron navigator 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC100120, AC122011, AC129336

UniProtKB/Swiss-Prot

Q80TN7

Conserved Domains (6) summary

smart00382
Location:2023 → 2143

AAA; ATPases associated with a variety of cellular activities

PHA03307
Location:979 → 1294

PHA03307; transcriptional regulator ICP4; Provisional

cd00014
Location:81 → 182

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

TIGR04211
Location:1573 → 1649

SH3_and_anchor; SH3 domain protein

pfam05109
Location:204 → 582

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam15898
Location:1768 → 1831

PRKG1_interact; cGMP-dependent protein kinase interacting domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

109517121..110292148 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155787.1 → XP_036011680.1 neuron navigator 3 isoform X4

UniProtKB/TrEMBL

A0A668KM70

Conserved Domains (5) summary

smart00382
Location:1973 → 2093

AAA; ATPases associated with a variety of cellular activities

PHA03307
Location:922 → 1237

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:1519 → 1779

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam05109
Location:147 → 525

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd21286
Location:24 → 126

CH_NAV3; calponin homology (CH) domain found in neuron navigator 3
XM_006513680.4 → XP_006513743.1 neuron navigator 3 isoform X8

Conserved Domains (7) summary

smart00382
Location:1853 → 1973

AAA; ATPases associated with a variety of cellular activities

PHA03307
Location:979 → 1297

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:1399 → 1659

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR04211
Location:1396 → 1472

SH3_and_anchor; SH3 domain protein

pfam05109
Location:204 → 582

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam00307
Location:81 → 182

CH; Calponin homology (CH) domain

pfam15898
Location:1607 → 1661

PRKG1_interact; cGMP-dependent protein kinase interacting domain
XM_006513679.4 → XP_006513742.1 neuron navigator 3 isoform X7

Conserved Domains (7) summary

smart00382
Location:1867 → 1987

AAA; ATPases associated with a variety of cellular activities

PHA03307
Location:979 → 1311

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:1413 → 1673

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR04211
Location:1410 → 1486

SH3_and_anchor; SH3 domain protein

pfam05109
Location:204 → 582

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam00307
Location:81 → 182

CH; Calponin homology (CH) domain

pfam15898
Location:1621 → 1675

PRKG1_interact; cGMP-dependent protein kinase interacting domain
XM_006513676.4 → XP_006513739.1 neuron navigator 3 isoform X1

Conserved Domains (7) summary

smart00382
Location:2016 → 2136

AAA; ATPases associated with a variety of cellular activities

PHA03307
Location:979 → 1294

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:1562 → 1822

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR04211
Location:1559 → 1635

SH3_and_anchor; SH3 domain protein

pfam05109
Location:204 → 582

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam00307
Location:81 → 182

CH; Calponin homology (CH) domain

pfam15898
Location:1770 → 1824

PRKG1_interact; cGMP-dependent protein kinase interacting domain
XM_006513677.4 → XP_006513740.1 neuron navigator 3 isoform X3

Conserved Domains (6) summary

smart00382
Location:2007 → 2127

AAA; ATPases associated with a variety of cellular activities

PHA03307
Location:956 → 1271

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:1553 → 1813

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR04211
Location:1550 → 1626

SH3_and_anchor; SH3 domain protein

pfam05109
Location:262 → 559

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam00307
Location:81 → 182

CH; Calponin homology (CH) domain
XM_017313948.3 → XP_017169437.1 neuron navigator 3 isoform X10

UniProtKB/TrEMBL

A0A571BDN3

Related

ENSMUSP00000158790.2, ENSMUST00000238286.2

Conserved Domains (6) summary

smart00382
Location:1515 → 1635

AAA; ATPases associated with a variety of cellular activities

PHA03307
Location:478 → 793

PHA03307; transcriptional regulator ICP4; Provisional

TIGR02169
Location:1050 → 1321

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

TIGR04211
Location:1058 → 1134

SH3_and_anchor; SH3 domain protein

pfam05109
Location:659 → 996

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam15898
Location:1269 → 1323

PRKG1_interact; cGMP-dependent protein kinase interacting domain
XM_006513681.5 → XP_006513744.1 neuron navigator 3 isoform X9

UniProtKB/TrEMBL

A0A571BDN3

Conserved Domains (6) summary

smart00382
Location:1529 → 1649

AAA; ATPases associated with a variety of cellular activities

PHA03307
Location:478 → 793

PHA03307; transcriptional regulator ICP4; Provisional

TIGR02169
Location:1064 → 1335

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

TIGR04211
Location:1072 → 1148

SH3_and_anchor; SH3 domain protein

pfam05109
Location:659 → 1010

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam15898
Location:1283 → 1337

PRKG1_interact; cGMP-dependent protein kinase interacting domain
XM_036155788.1 → XP_036011681.1 neuron navigator 3 isoform X5

Conserved Domains (5) summary

smart00382
Location:1950 → 2070

AAA; ATPases associated with a variety of cellular activities

PHA03307
Location:899 → 1214

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:1496 → 1756

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam05109
Location:205 → 502

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd21286
Location:24 → 126

CH_NAV3; calponin homology (CH) domain found in neuron navigator 3
XM_017313946.3 → XP_017169435.1 neuron navigator 3 isoform X4

UniProtKB/TrEMBL

A0A668KM70

Related

ENSMUSP00000159239.2, ENSMUST00000239301.2

Conserved Domains (5) summary

smart00382
Location:1973 → 2093

AAA; ATPases associated with a variety of cellular activities

PHA03307
Location:922 → 1237

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:1519 → 1779

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam05109
Location:147 → 525

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd21286
Location:24 → 126

CH_NAV3; calponin homology (CH) domain found in neuron navigator 3
XM_017313945.2 → XP_017169434.1 neuron navigator 3 isoform X2

Conserved Domains (6) summary

smart00382
Location:2009 → 2129

AAA; ATPases associated with a variety of cellular activities

PHA03307
Location:979 → 1294

PHA03307; transcriptional regulator ICP4; Provisional

TIGR04211
Location:1559 → 1635

SH3_and_anchor; SH3 domain protein

pfam05109
Location:204 → 582

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam00307
Location:81 → 182

CH; Calponin homology (CH) domain

pfam15898
Location:1763 → 1817

PRKG1_interact; cGMP-dependent protein kinase interacting domain
XM_036155789.1 → XP_036011682.1 neuron navigator 3 isoform X6

Conserved Domains (5) summary

smart00382
Location:1893 → 2013

AAA; ATPases associated with a variety of cellular activities

PHA03307
Location:842 → 1157

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:1439 → 1699

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam05109
Location:67 → 445

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl00030
Location:1 → 46

CH_SF; calponin homology (CH) domain superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_177797.2: Suppressed sequence

Description

NM_177797.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.