Ctps1 CTP synthase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ctps1provided by RGD
Official Full Name: CTP synthase 1provided by RGD
Primary source: RGD:1311060
See related: EnsemblRapid:ENSRNOG00000009963 AllianceGenome:RGD:1311060
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ctps
Summary: Predicted to enable CTP synthase activity and identical protein binding activity. Predicted to be involved in CTP biosynthetic process; lymphocyte proliferation; and pyrimidine nucleobase biosynthetic process. Predicted to be active in cytoophidium and cytoplasm. Human ortholog(s) of this gene implicated in immunodeficiency 24. Orthologous to human CTPS1 (CTP synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 289.2), Brain (RPKM 222.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (139372349..139440441, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (134125022..134154155, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (139475934..139505065, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CTPS1 inhibition selectively blocks smooth muscle cell proliferation without disturbing or even promoting re-endothelialization for effective vascular repair after injury.
Title: CTP synthase 1, a smooth muscle-sensitive therapeutic target for effective vascular repair.

Submit: New GeneRIF Correction

General gene information

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Markers

D5Got70 (e-PCR)
- UniSTS:111977

BF408166 (e-PCR)
- UniSTS:248748

Ctps (e-PCR), detects polymorphism
- UniSTS:166614

RH142657 (e-PCR)
- UniSTS:231904

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CTP synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables CTP synthase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 'de novo' CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in CTP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in CTP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in glutamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine nucleobase biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoophidium	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoophidium	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CTP synthase 1

Names: cytidine 5'-triphosphate synthase

NP_001128345.1

EC 6.3.4.2

XP_006238843.1

EC 6.3.4.2

XP_063143816.1

EC 6.3.4.2

XP_063143817.1

EC 6.3.4.2

XP_063143818.1

EC 6.3.4.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.