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    Zfp334 zinc finger protein 334 [ Mus musculus (house mouse) ]

    Gene ID: 228876, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp334provided by MGI
    Official Full Name
    zinc finger protein 334provided by MGI
    Primary source
    MGI:MGI:2388656
    See related
    Ensembl:ENSMUSG00000017667 AllianceGenome:MGI:2388656
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D2Ertd535e
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; brain; eye; genitourinary system; and spinal cord. Orthologous to human ZNF334 (zinc finger protein 334). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 11.8), whole brain E14.5 (RPKM 7.8) and 21 other tissues See more
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    Genomic context

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    See Zfp334 in Genome Data Viewer
    Location:
    2 H3; 2 85.53 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (165216184..165230234, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (165374264..165388315, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene engulfment and cell motility 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:165147221-165147404 Neighboring gene STARR-positive B cell enhancer ABC_E418 Neighboring gene zinc finger protein 663 Neighboring gene STARR-seq mESC enhancer starr_06348 Neighboring gene predicted gene, 29831 Neighboring gene osteoclast stimulatory transmembrane protein Neighboring gene solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 Neighboring gene origin of replication near adenosine deaminase Neighboring gene predicted gene 14437

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC27911

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 334

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178411.3 → NP_848498.2  zinc finger protein 334

      See identical proteins and their annotated locations for NP_848498.2

      Status: VALIDATED

      Source sequence(s)
      AL591064
      Consensus CDS
      CCDS17079.1
      UniProtKB/TrEMBL
      A2A4U6, Q8CGF0
      Related
      ENSMUSP00000099373.4, ENSMUST00000103084.4
      Conserved Domains (3) summary
      smart00349
      Location:9 → 68
      KRAB; krueppel associated box
      COG5048
      Location:262 → 678
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:238 → 258
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      165216184..165230234 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161641.1 → XP_036017534.1  zinc finger protein 334 isoform X4

      UniProtKB/TrEMBL
      Q8CGF0
      Conserved Domains (3) summary
      smart00349
      Location:9 → 68
      KRAB; krueppel associated box
      COG5048
      Location:261 → 677
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:237 → 257
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_036161639.1 → XP_036017532.1  zinc finger protein 334 isoform X1

      UniProtKB/TrEMBL
      Q8CGF0
      Conserved Domains (3) summary
      smart00349
      Location:20 → 79
      KRAB; krueppel associated box
      COG5048
      Location:273 → 689
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:249 → 269
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_011239500.3 → XP_011237802.1  zinc finger protein 334 isoform X2

      UniProtKB/TrEMBL
      Q8CGF0
      Conserved Domains (3) summary
      smart00349
      Location:20 → 79
      KRAB; krueppel associated box
      COG5048
      Location:272 → 688
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:248 → 268
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_006499377.5 → XP_006499440.1  zinc finger protein 334 isoform X1

      UniProtKB/TrEMBL
      Q8CGF0
      Conserved Domains (3) summary
      smart00349
      Location:20 → 79
      KRAB; krueppel associated box
      COG5048
      Location:273 → 689
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:249 → 269
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_036161640.1 → XP_036017533.1  zinc finger protein 334 isoform X3

      UniProtKB/TrEMBL
      A2A4U6, Q8CGF0
      Conserved Domains (3) summary
      smart00349
      Location:9 → 68
      KRAB; krueppel associated box
      COG5048
      Location:262 → 678
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:238 → 258
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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