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    Myo5c myosin VC [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315820, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Myo5cprovided by RGD
    Official Full Name
    myosin VCprovided by RGD
    Primary source
    RGD:1309994
    See related
    EnsemblRapid:ENSRNOG00000008356 AllianceGenome:RGD:1309994
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and vesicle transport along actin filament. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; cytoplasm; and vesicle. Orthologous to human MYO5C (myosin VC). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 175.4), Spleen (RPKM 70.9) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myo5c in Genome Data Viewer
    Location:
    8q24
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (84870031..84946996)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (75989497..76066485)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (82171296..82248109)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene cAMP-regulated phosphoprotein 19 Neighboring gene myosin VA Neighboring gene small nucleolar RNA U3 Neighboring gene G protein subunit beta 5 Neighboring gene Bcl2-like 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    unconventional myosin-Vc
    Names
    myosin-Vc

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108167.3 → NP_001101637.2  unconventional myosin-Vc

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I1B7
      Related
      ENSRNOP00000011768.8, ENSRNOT00000011768.9
      Conserved Domains (5) summary
      smart00015
      Location:755 → 776
      IQ; Calmodulin-binding motif
      cd15476
      Location:1369 → 1736
      Myo5c_CBD; Cargo binding domain of myosin 5C
      TIGR02168
      Location:850 → 1378
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01380
      Location:81 → 741
      MYSc_Myo5; class V myosin, motor domain
      pfam00612
      Location:831 → 851
      IQ; IQ calmodulin-binding motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      84870031..84946996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243413.4 → XP_006243475.1  unconventional myosin-Vc isoform X1

      See identical proteins and their annotated locations for XP_006243475.1

      UniProtKB/TrEMBL
      A6I1B7, F1M111
      Conserved Domains (9) summary
      smart00015
      Location:755 → 776
      IQ; Calmodulin-binding motif
      smart00242
      Location:62 → 752
      MYSc; Myosin. Large ATPases
      COG1340
      Location:890 → 1150
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd15476
      Location:1376 → 1743
      Myo5c_CBD; Cargo binding domain of myosin 5C
      cd01380
      Location:81 → 741
      MYSc_Myo5; class V myosin, motor domain
      pfam02736
      Location:12 → 48
      Myosin_N; Myosin N-terminal SH3-like domain
      cd16269
      Location:1001 → 1010
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:929 → 1030
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:977 → 1096
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. XM_063265550.1 → XP_063121620.1  unconventional myosin-Vc isoform X2

    RNA

    1. XR_001839460.3 RNA Sequence

    2. XR_594031.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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