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    Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit [ Mus musculus (house mouse) ]

    Gene ID: 14056, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ezh2provided by MGI
    Official Full Name
    enhancer of zeste 2 polycomb repressive complex 2 subunitprovided by MGI
    Primary source
    MGI:MGI:107940
    See related
    Ensembl:ENSMUSG00000029687 AllianceGenome:MGI:107940
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KMT6; Enx-1; Enx1h; mKIAA4065
    Summary
    Enables several functions, including histone H3K27 methyltransferase activity; nucleic acid binding activity; and transcription corepressor activity. Involved in B cell differentiation; facultative heterochromatin formation; and regulation of circadian rhythm. Acts upstream of or within several processes, including cardiac muscle hypertrophy in response to stress; negative regulation of cell differentiation; and regulation of DNA-templated transcription. Located in pericentric heterochromatin and pronucleus. Part of ESC/E(Z) complex and chromatin silencing complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and integumental system. Used to study B-cell lymphoma; Weaver syndrome; and acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Weaver syndrome; gastrointestinal system cancer (multiple); glioblastoma; hematologic cancer (multiple); and renal Wilms' tumor. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in CNS E11.5 (RPKM 46.4), CNS E14 (RPKM 30.5) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ezh2 in Genome Data Viewer
    Location:
    6 B2.3; 6 22.92 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (47507208..47613843, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (47530274..47595270, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene TAR (HIV) RNA binding protein 2 pseudogene Neighboring gene cullin 1 Neighboring gene STARR-seq mESC enhancer starr_15778 Neighboring gene RIKEN cDNA F830010H11 gene Neighboring gene STARR-positive B cell enhancer mm9_chr6:47544952-47545253 Neighboring gene STARR-seq mESC enhancer starr_15780 Neighboring gene STARR-seq mESC enhancer starr_15781 Neighboring gene STARR-positive B cell enhancer ABC_E4823 Neighboring gene predicted gene, 40371 Neighboring gene predicted gene, 40369 Neighboring gene 4.5S RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • KIAA4065, MGC90723

    Gene Ontology Provided by MGI

    Items 1 - 25 of 33
    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables RNA binding PubMed 
    enables RNA binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II core promoter sequence-specific DNA binding PubMed 
    enables RNA polymerase II core promoter sequence-specific DNA binding PubMed 
    enables chromatin DNA binding PubMed 
    enables chromatin DNA binding  
    enables chromatin binding  
    enables chromatin binding PubMed 
    enables chromatin binding  
    enables histone H3K27 methyltransferase activity  
    enables histone H3K27 methyltransferase activity PubMed 
    enables histone H3K27 methyltransferase activity  
    enables histone H3K27 methyltransferase activity  
    enables histone H3K27 trimethyltransferase activity  
    enables histone binding  
    enables histone methyltransferase activity PubMed 
    enables histone methyltransferase activity  
    enables lncRNA binding PubMed 
    enables nucleosome binding  
    enables primary miRNA binding PubMed 
    enables promoter-specific chromatin binding  
    enables promoter-specific chromatin binding  
    enables protein binding PubMed 
    enables protein-lysine N-methyltransferase activity PubMed 
    enables protein-lysine N-methyltransferase activity PubMed 
    enables ribonucleoprotein complex binding PubMed 
    enables sequence-specific DNA binding PubMed 
    enables transcription cis-regulatory region binding  
    enables transcription corepressor activity PubMed 
    enables transcription corepressor binding  
    enables transcription corepressor binding  
    Items 1 - 25 of 33
    Items 1 - 25 of 77
    Process Evidence Code Pubs
    involved_in B cell differentiation PubMed 
    acts_upstream_of_or_within DNA methylation-dependent constitutive heterochromatin formation PubMed 
    acts_upstream_of_or_within G1 to G0 transition PubMed 
    acts_upstream_of G1/S transition of mitotic cell cycle PubMed 
    acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress PubMed 
    acts_upstream_of_or_within cellular response to hydrogen peroxide PubMed 
    acts_upstream_of_or_within cellular response to trichostatin A PubMed 
    acts_upstream_of_or_within cerebellar cortex development PubMed 
    involved_in chromatin remodeling  
    acts_upstream_of epidermal cell differentiation PubMed 
    involved_in facultative heterochromatin formation PubMed 
    involved_in hemopoiesis PubMed 
    acts_upstream_of_or_within hepatocyte homeostasis PubMed 
    involved_in heterochromatin formation  
    involved_in hippocampus development  
    involved_in immunoglobulin heavy chain V-D-J recombination PubMed 
    acts_upstream_of keratinocyte differentiation PubMed 
    acts_upstream_of_or_within liver regeneration PubMed 
    involved_in methylation  
    acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle PubMed 
    involved_in negative regulation of cytokine production involved in inflammatory response  
    involved_in negative regulation of cytokine production involved in inflammatory response  
    acts_upstream_of_or_within negative regulation of epidermal cell differentiation PubMed 
    involved_in negative regulation of gene expression  
    involved_in negative regulation of gene expression, epigenetic  
    involved_in negative regulation of gene expression, epigenetic  
    acts_upstream_of_or_within negative regulation of keratinocyte differentiation PubMed 
    involved_in negative regulation of retinoic acid receptor signaling pathway  
    involved_in negative regulation of retinoic acid receptor signaling pathway  
    acts_upstream_of_or_within negative regulation of stem cell differentiation PubMed 
    acts_upstream_of_or_within negative regulation of striated muscle cell differentiation PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of transcription elongation by RNA polymerase II PubMed 
    involved_in positive regulation of GTPase activity  
    involved_in positive regulation of GTPase activity  
    involved_in positive regulation of MAP kinase activity  
    involved_in positive regulation of MAP kinase activity  
    involved_in positive regulation of cell cycle G1/S phase transition  
    involved_in positive regulation of cell cycle G1/S phase transition  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of dendrite development  
    involved_in positive regulation of dendrite development  
    involved_in positive regulation of epithelial to mesenchymal transition  
    involved_in positive regulation of epithelial to mesenchymal transition  
    involved_in positive regulation of protein serine/threonine kinase activity  
    involved_in positive regulation of protein serine/threonine kinase activity  
    acts_upstream_of_or_within protein localization to chromatin PubMed 
    involved_in protein modification process  
    involved_in protein modification process  
    acts_upstream_of_or_within regulation of cell population proliferation PubMed 
    involved_in regulation of circadian rhythm PubMed 
    involved_in regulation of circadian rhythm  
    acts_upstream_of_or_within regulation of gene expression PubMed 
    acts_upstream_of_or_within regulation of gliogenesis PubMed 
    involved_in regulation of kidney development  
    acts_upstream_of_or_within regulation of neurogenesis PubMed 
    acts_upstream_of_or_within regulation of protein phosphorylation PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II PubMed 
    involved_in regulatory ncRNA-mediated heterochromatin formation  
    involved_in regulatory ncRNA-mediated heterochromatin formation  
    involved_in response to estradiol  
    acts_upstream_of_or_within response to tetrachloromethane PubMed 
    involved_in rhythmic process  
    acts_upstream_of_or_within skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration PubMed 
    acts_upstream_of stem cell differentiation PubMed 
    involved_in subtelomeric heterochromatin formation  
    involved_in subtelomeric heterochromatin formation  
    involved_in synaptic transmission, GABAergic  
    involved_in synaptic transmission, GABAergic  
    Items 1 - 25 of 77
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex  
    part_of ESC/E(Z) complex PubMed 
    part_of ESC/E(Z) complex  
    located_in chromatin  
    part_of chromatin silencing complex PubMed 
    is_active_in chromosome  
    located_in chromosome, telomeric region  
    located_in chromosome, telomeric region  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    is_active_in nucleus PubMed 
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus PubMed 
    located_in pericentric heterochromatin PubMed 
    located_in pronucleus PubMed 
    located_in synapse  

    General protein information

    Preferred Names
    histone-lysine N-methyltransferase EZH2
    Names
    enhancer of zeste homolog 2
    NP_001140161.1
    NP_001396739.1
    NP_001396740.1
    NP_001396741.1
    NP_001396742.1
    NP_001396743.1
    NP_001396744.1
    NP_001396745.1
    NP_001396746.1
    NP_001396747.1
    NP_001396748.1
    NP_001396749.1
    NP_001396750.1
    NP_001396751.1
    NP_001396752.1
    NP_001396753.1
    NP_001396754.1
    NP_001396755.1
    NP_001396756.1
    NP_001396757.1
    NP_001396758.1
    NP_001396759.1
    NP_001396760.1
    NP_031997.2
    XP_006505590.1
    XP_030111015.1
    XP_036021710.1
    XP_036021711.1
    XP_036021712.1
    XP_036021713.1
    XP_036021715.1
    XP_036021716.1
    XP_036021720.1
    XP_036021721.1
    XP_036021722.1
    XP_036021724.1
    XP_036021725.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146689.1NP_001140161.1  histone-lysine N-methyltransferase EZH2 isoform 2

      See identical proteins and their annotated locations for NP_001140161.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This difference results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK157853, AK220174, BC079538
      Consensus CDS
      CCDS51760.1
      UniProtKB/TrEMBL
      Q3TZH6, Q6AXH7
      Related
      ENSMUSP00000110265.2, ENSMUST00000114618.8
      Conserved Domains (4) summary
      cd19218
      Location:605724
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:149240
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:555586
      preSET_CXC; CXC domain
    2. NM_001409810.1NP_001396739.1  histone-lysine N-methyltransferase EZH2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
      UniProtKB/TrEMBL
      Q3TZH6
    3. NM_001409811.1NP_001396740.1  histone-lysine N-methyltransferase EZH2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
      UniProtKB/TrEMBL
      Q3TZH6
    4. NM_001409812.1NP_001396741.1  histone-lysine N-methyltransferase EZH2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
      UniProtKB/TrEMBL
      Q3TZH6
    5. NM_001409813.1NP_001396742.1  histone-lysine N-methyltransferase EZH2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
      UniProtKB/Swiss-Prot
      Q61188, Q99L74, Q9R090
      UniProtKB/TrEMBL
      Q3TZH6
    6. NM_001409814.1NP_001396743.1  histone-lysine N-methyltransferase EZH2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
      UniProtKB/Swiss-Prot
      Q61188, Q99L74, Q9R090
      UniProtKB/TrEMBL
      Q3TZH6
    7. NM_001409815.1NP_001396744.1  histone-lysine N-methyltransferase EZH2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
      UniProtKB/Swiss-Prot
      Q61188, Q99L74, Q9R090
      UniProtKB/TrEMBL
      Q3TZH6
    8. NM_001409816.1NP_001396745.1  histone-lysine N-methyltransferase EZH2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
      UniProtKB/Swiss-Prot
      Q61188, Q99L74, Q9R090
      UniProtKB/TrEMBL
      Q3TZH6
    9. NM_001409817.1NP_001396746.1  histone-lysine N-methyltransferase EZH2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
      UniProtKB/Swiss-Prot
      Q61188, Q99L74, Q9R090
      UniProtKB/TrEMBL
      Q3TZH6
    10. NM_001409818.1NP_001396747.1  histone-lysine N-methyltransferase EZH2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
      UniProtKB/TrEMBL
      Q3TZH6
    11. NM_001409819.1NP_001396748.1  histone-lysine N-methyltransferase EZH2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
      UniProtKB/TrEMBL
      Q3TZH6
    12. NM_001409820.1NP_001396749.1  histone-lysine N-methyltransferase EZH2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
      UniProtKB/TrEMBL
      Q3TZH6
    13. NM_001409821.1NP_001396750.1  histone-lysine N-methyltransferase EZH2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
      UniProtKB/TrEMBL
      Q3TZH6
    14. NM_001409822.1NP_001396751.1  histone-lysine N-methyltransferase EZH2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
      UniProtKB/TrEMBL
      Q3TZH6
    15. NM_001409823.1NP_001396752.1  histone-lysine N-methyltransferase EZH2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
      UniProtKB/TrEMBL
      Q3TZH6
    16. NM_001409824.1NP_001396753.1  histone-lysine N-methyltransferase EZH2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
      UniProtKB/TrEMBL
      Q3TZH6
      Related
      ENSMUSP00000090318.7, ENSMUST00000092648.13
    17. NM_001409825.1NP_001396754.1  histone-lysine N-methyltransferase EZH2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
      UniProtKB/TrEMBL
      Q3TZH6
    18. NM_001409826.1NP_001396755.1  histone-lysine N-methyltransferase EZH2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
      UniProtKB/TrEMBL
      Q3TZH6
    19. NM_001409827.1NP_001396756.1  histone-lysine N-methyltransferase EZH2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
      UniProtKB/TrEMBL
      Q3TZH6
    20. NM_001409828.1NP_001396757.1  histone-lysine N-methyltransferase EZH2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
      UniProtKB/TrEMBL
      Q3TZH6
    21. NM_001409829.1NP_001396758.1  histone-lysine N-methyltransferase EZH2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
      UniProtKB/TrEMBL
      Q3TZH6
    22. NM_001409830.1NP_001396759.1  histone-lysine N-methyltransferase EZH2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
      UniProtKB/TrEMBL
      Q3TZH6
    23. NM_001409831.1NP_001396760.1  histone-lysine N-methyltransferase EZH2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
      UniProtKB/TrEMBL
      D3Z774
    24. NM_007971.2NP_031997.2  histone-lysine N-methyltransferase EZH2 isoform 1

      See identical proteins and their annotated locations for NP_031997.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). This isoform is also known as ENX-1A.
      Source sequence(s)
      AK157853, AK220174, BC079538
      Consensus CDS
      CCDS20096.1
      UniProtKB/Swiss-Prot
      Q61188, Q99L74, Q9R090
      UniProtKB/TrEMBL
      Q3TZH6
      Related
      ENSMUSP00000080419.7, ENSMUST00000081721.13
      Conserved Domains (4) summary
      cd19218
      Location:609728
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:158249
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:559590
      preSET_CXC; CXC domain

    RNA

    1. NR_176898.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
    2. NR_176899.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
    3. NR_176900.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
    4. NR_176901.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
    5. NR_176902.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652
    6. NR_176903.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154015, AC155652

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      47507208..47613843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165829.1XP_036021722.1  histone-lysine N-methyltransferase EZH2 isoform X10

      UniProtKB/TrEMBL
      D3Z774
      Conserved Domains (3) summary
      cd19218
      Location:500619
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam18118
      Location:49140
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:450481
      preSET_CXC; CXC domain
    2. XM_036165828.1XP_036021721.1  histone-lysine N-methyltransferase EZH2 isoform X9

      UniProtKB/TrEMBL
      D3Z774
      Conserved Domains (3) summary
      cd19218
      Location:505624
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam18118
      Location:49140
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:455486
      preSET_CXC; CXC domain
    3. XM_036165832.1XP_036021725.1  histone-lysine N-methyltransferase EZH2 isoform X11

      Conserved Domains (2) summary
      cd19218
      Location:377496
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam18264
      Location:327358
      preSET_CXC; CXC domain
    4. XM_030255155.1XP_030111015.1  histone-lysine N-methyltransferase EZH2 isoform X13

      Conserved Domains (2) summary
      pfam18264
      Location:285316
      preSET_CXC; CXC domain
      cd19218
      Location:335454
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    5. XM_006505527.2XP_006505590.1  histone-lysine N-methyltransferase EZH2 isoform X11

      See identical proteins and their annotated locations for XP_006505590.1

      Conserved Domains (2) summary
      cd19218
      Location:377496
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam18264
      Location:327358
      preSET_CXC; CXC domain
    6. XM_036165827.1XP_036021720.1  histone-lysine N-methyltransferase EZH2 isoform X8

      UniProtKB/TrEMBL
      Q3TZH6
      Conserved Domains (4) summary
      cd19218
      Location:558677
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:149240
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:508539
      preSET_CXC; CXC domain
    7. XM_036165823.1XP_036021716.1  histone-lysine N-methyltransferase EZH2 isoform X3

      UniProtKB/TrEMBL
      Q3TZH6, Q6AXH7
      Conserved Domains (4) summary
      cd19218
      Location:605724
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:149240
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:555586
      preSET_CXC; CXC domain
    8. XM_036165831.1XP_036021724.1  histone-lysine N-methyltransferase EZH2 isoform X11

      Conserved Domains (2) summary
      cd19218
      Location:377496
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam18264
      Location:327358
      preSET_CXC; CXC domain
    9. XM_036165817.1XP_036021710.1  histone-lysine N-methyltransferase EZH2 isoform X1

      UniProtKB/TrEMBL
      Q3TZH6
      Conserved Domains (4) summary
      cd19218
      Location:614733
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:158249
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:564595
      preSET_CXC; CXC domain
    10. XM_036165820.1XP_036021713.1  histone-lysine N-methyltransferase EZH2 isoform X2

      UniProtKB/Swiss-Prot
      Q61188, Q99L74, Q9R090
      UniProtKB/TrEMBL
      Q3TZH6
      Conserved Domains (4) summary
      cd19218
      Location:609728
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:158249
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:559590
      preSET_CXC; CXC domain
    11. XM_036165818.1XP_036021711.1  histone-lysine N-methyltransferase EZH2 isoform X1

      UniProtKB/TrEMBL
      Q3TZH6
      Conserved Domains (4) summary
      cd19218
      Location:614733
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:158249
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:564595
      preSET_CXC; CXC domain
    12. XM_036165822.1XP_036021715.1  histone-lysine N-methyltransferase EZH2 isoform X2

      UniProtKB/Swiss-Prot
      Q61188, Q99L74, Q9R090
      UniProtKB/TrEMBL
      Q3TZH6
      Conserved Domains (4) summary
      cd19218
      Location:609728
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:158249
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:559590
      preSET_CXC; CXC domain
    13. XM_036165819.1XP_036021712.1  histone-lysine N-methyltransferase EZH2 isoform X1

      UniProtKB/TrEMBL
      Q3TZH6
      Conserved Domains (4) summary
      cd19218
      Location:614733
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:158249
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:564595
      preSET_CXC; CXC domain
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