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    Pidd1 p53-induced death domain protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293625, updated on 9-Dec-2024

    Summary

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    Symbol
    Pidd1provided by RGD
    Full Name
    p53-induced death domain protein 1provided by RGD
    Primary source
    RGD:1311792
    See related
    EnsemblRapid:ENSRNOG00000049179 AllianceGenome:RGD:1311792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lrdd; Pidd
    Summary
    Predicted to enable endopeptidase activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; protein autoprocessing; and regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process and extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in Golgi apparatus; cytosol; and nucleus. Predicted to be part of endopeptidase complex. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 75. Orthologous to human PIDD1 (p53-induced death domain protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 27.6), Spleen (RPKM 22.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pidd1 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205966392..205972359, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196536815..196542808, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (214418751..214423959, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glutamine amidotransferase class 1 domain containing 1 Neighboring gene solute carrier family 25 member 22 Neighboring gene cell cycle exit and neuronal differentiation 1 Neighboring gene ribosomal protein lateral stalk subunit P2 Neighboring gene small nucleolar RNA, H/ACA box 52 Neighboring gene patatin-like phospholipase domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The expression and role of PIDD in retina after optic nerve crush. Tang F, et al. J Mol Histol, 2020 Feb. PMID 32065357
    2. Involvement of Upregulated P53-Induced Death Domain Protein in Retinal Ganglion Cells Apoptosis After Optic Nerve Crush. Zhang M, et al. Curr Mol Med, 2019. PMID 31533600
    3. Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway. Tinel A, et al. EMBO J, 2007 Jan 10. PMID 17159900, Free PMC Article
    4. Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Oliver TG, et al. Mol Cell, 2011 Jul 8. PMID 21726810, Free PMC Article
    5. Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD. Berube C, et al. Proc Natl Acad Sci U S A, 2005 Oct 4. PMID 16183742, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Involvement of Upregulated P53-Induced Death Domain Protein in Retinal Ganglion Cells Apoptosis After Optic Nerve Crush.
      Title: Involvement of Upregulated P53-Induced Death Domain Protein in Retinal Ganglion Cells Apoptosis After Optic Nerve Crush.
    2. The expression and role of PIDD in retina after optic nerve crush.
      Title: The expression and role of PIDD in retina after optic nerve crush.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autoprocessing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of endopeptidase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    p53-induced death domain-containing protein 1
    Names
    leucine-rich repeats and death domain containing
    p53-induced protein with a death domain-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106318.2 → NP_001099788.2  p53-induced death domain-containing protein 1

      See identical proteins and their annotated locations for NP_001099788.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      M0R797
      Related
      ENSRNOP00000065320.1, ENSRNOT00000072774.3
      Conserved Domains (5) summary
      COG4886
      Location:135 → 296
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd08779
      Location:795 → 880
      Death_PIDD; Death Domain of p53-induced protein with a death domain
      sd00033
      Location:132 → 154
      LRR_RI; leucine-rich repeat [structural motif]
      pfam10461
      Location:428 → 460
      Peptidase_S68; Peptidase S68
      cl02517
      Location:330 → 403
      ZU5; ZU5 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      205966392..205972359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107985.2 → XP_038963913.1  p53-induced death domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      M0R797
      Conserved Domains (5) summary
      COG4886
      Location:135 → 296
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd08779
      Location:795 → 880
      Death_PIDD; Death Domain of p53-induced protein with a death domain
      sd00033
      Location:132 → 154
      LRR_RI; leucine-rich repeat [structural motif]
      pfam10461
      Location:428 → 460
      Peptidase_S68; Peptidase S68
      cl02517
      Location:330 → 403
      ZU5; ZU5 domain

    2. XM_039108000.2 → XP_038963928.1  p53-induced death domain-containing protein 1 isoform X2

      Conserved Domains (5) summary
      COG4886
      Location:135 → 296
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd08779
      Location:779 → 864
      Death_PIDD; Death Domain of p53-induced protein with a death domain
      sd00033
      Location:132 → 154
      LRR_RI; leucine-rich repeat [structural motif]
      pfam10461
      Location:428 → 460
      Peptidase_S68; Peptidase S68
      cl02517
      Location:330 → 403
      ZU5; ZU5 domain

    3. XM_039107978.2 → XP_038963906.1  p53-induced death domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      M0R797
      Conserved Domains (5) summary
      COG4886
      Location:135 → 296
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd08779
      Location:795 → 880
      Death_PIDD; Death Domain of p53-induced protein with a death domain
      sd00033
      Location:132 → 154
      LRR_RI; leucine-rich repeat [structural motif]
      pfam10461
      Location:428 → 460
      Peptidase_S68; Peptidase S68
      cl02517
      Location:330 → 403
      ZU5; ZU5 domain

    4. XM_039107989.2 → XP_038963917.1  p53-induced death domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      M0R797
      Conserved Domains (5) summary
      COG4886
      Location:135 → 296
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd08779
      Location:795 → 880
      Death_PIDD; Death Domain of p53-induced protein with a death domain
      sd00033
      Location:132 → 154
      LRR_RI; leucine-rich repeat [structural motif]
      pfam10461
      Location:428 → 460
      Peptidase_S68; Peptidase S68
      cl02517
      Location:330 → 403
      ZU5; ZU5 domain

    5. XM_039108008.2 → XP_038963936.1  p53-induced death domain-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      A6HXX6
      Conserved Domains (3) summary
      cd08779
      Location:477 → 562
      Death_PIDD; Death Domain of p53-induced protein with a death domain
      pfam10461
      Location:110 → 142
      Peptidase_S68; Peptidase S68
      cl02517
      Location:12 → 85
      ZU5; ZU5 domain

    6. XM_063286610.1 → XP_063142680.1  p53-induced death domain-containing protein 1 isoform X3

    7. XM_039108007.2 → XP_038963935.1  p53-induced death domain-containing protein 1 isoform X4

      Conserved Domains (4) summary
      COG4886
      Location:135 → 296
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:132 → 154
      LRR_RI; leucine-rich repeat [structural motif]
      pfam10461
      Location:428 → 460
      Peptidase_S68; Peptidase S68
      cl02517
      Location:330 → 403
      ZU5; ZU5 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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