Sfrp5 secreted frizzled-related protein 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sfrp5provided by RGD
Official Full Name: secreted frizzled-related protein 5provided by RGD
Primary source: RGD:1310369
See related: EnsemblRapid:ENSRNOG00000014940 AllianceGenome:RGD:1310369
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable Wnt-protein binding activity. Predicted to be involved in several processes, including Wnt signaling pathway; negative regulation of signal transduction; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including convergent extension involved in axis elongation; negative regulation of JUN kinase activity; and post-anal tail morphogenesis. Predicted to be active in extracellular space. Orthologous to human SFRP5 (secreted frizzled related protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 37.5), Adrenal (RPKM 11.1) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (250956050..250960512, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (241006762..241011224, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (261442108..261446570, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Secreted Frizzled-Related Protein 5 Ameliorates Vascular Calcification in a Rat Model of Chronic Kidney Disease through the Wnt/beta-Catenin Pathway.
Title: Secreted Frizzled-Related Protein 5 Ameliorates Vascular Calcification in a Rat Model of Chronic Kidney Disease through the Wnt/β-Catenin Pathway.
Reduction of Secreted Frizzled-Related Protein 5 Drives Vascular Calcification through Wnt3a-Mediated Rho/ROCK/JNK Signaling in Chronic Kidney Disease.
Title: Reduction of Secreted Frizzled-Related Protein 5 Drives Vascular Calcification through Wnt3a-Mediated Rho/ROCK/JNK Signaling in Chronic Kidney Disease.
Central Sfrp5 signaling activates a previously unappreciated InsR-Akt-PI3k-KATP channel pathway in the hypothalamus and brain-hepatic vagus neurocircuitry to decrease hepatic glucose production and VLDL-triglyceride secretion.
Title: Central Sfrp5 regulates hepatic glucose flux and VLDL-triglyceride secretion.
Sfrp5 reduces markers of cell proliferation, but increases in parallel dose-dependently glucose-stimulated insulin secretion in INS-1E cells
Title: Sfrp5 increases glucose-stimulated insulin secretion in the rat pancreatic beta cell line INS-1E.
the present results suggested that SFRP5 may inhibit SMC proliferation, migration and inflammation by suppressing the Wnt/bcatenin and p38/mitogenactivated protein kinase signaling pathways.
Title: SFRP5 serves a beneficial role in arterial aging by inhibiting the proliferation, migration and inflammation of smooth muscle cells.
Sfrp5 level was significantly reduced in high glucose-treated INS-1 cells, primary rat beta-cells, and islets isolated from glucose-infused rats. Overexpression of SFRP5 diminished glucose-stimulated proliferation in both INS-1 cells and primary beta-cells, with a concomitant inhibition of the Wnt signaling pathway and decreased cyclin D2 expression.
Title: Sfrp5 mediates glucose-induced proliferation in rat pancreatic β-cells.
Study demonstrates that sFRP5 is expressed in cardiomyocytes and upregulated in cardiomyocyte hypertrophy, and may play a critical role in reversing the progression of myocardial hypertrophy and cardiomyopathy.
Title: Angiotensin II increases secreted frizzled-related protein 5 (sFRP5) expression through AT1 receptor/Rho/ROCK1/JNK signaling in cardiomyocytes.
Findings reveal an important role for SFRP5 and Wnt signalling in the regulation of beta cell proliferation in obesity.
Title: Downregulation of Sfrp5 promotes beta cell proliferation during obesity in the rat.
Sfrp5 were primarily present in the resting zone of in growth plate cartilage of 1-week-old rats.
Title: Spatial and temporal regulation of gene expression in the mammalian growth plate.

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General gene information

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Markers

Sfrp5 (e-PCR), detects polymorphism
- UniSTS:507221

Sfrp5 (e-PCR), detects polymorphism
- UniSTS:525512

AA899309 (e-PCR)
- UniSTS:244212

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within convergent extension involved in axis elongation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within post-anal tail morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of establishment of planar polarity	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: secreted frizzled-related protein 5

Names: secreted frizzled-related sequence protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107591.1 → NP_001101061.1 secreted frizzled-related protein 5 precursor

See identical proteins and their annotated locations for NP_001101061.1

Status: PROVISIONAL

Source sequence(s)

CH473986

UniProtKB/TrEMBL

A6JHB1, D3ZTV6

Related

ENSRNOP00000020182.4, ENSRNOT00000020182.7

Conserved Domains (2) summary

cd07444
Location:44 → 170

CRD_SFRP5; Cysteine-rich domain of the secreted frizzled-related protein 5 (SFRP5), a regulator of Wnt activity

cd03580
Location:175 → 300

NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...