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    Sorcs2 sortilin-related VPS10 domain containing receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305438, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sorcs2provided by RGD
    Official Full Name
    sortilin-related VPS10 domain containing receptor 2provided by RGD
    Primary source
    RGD:1310621
    See related
    EnsemblRapid:ENSRNOG00000007033 AllianceGenome:RGD:1310621
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in intracellular protein transport and long-term synaptic depression. Predicted to be located in several cellular components, including cytosol; endosome membrane; and postsynaptic density. Predicted to be active in membrane. Orthologous to human SORCS2 (sortilin related VPS10 domain containing receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 88.5), Brain (RPKM 65.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sorcs2 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (78592290..78960582)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (74371089..74735943)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (79538911..79912333)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene transcriptional adaptor 2B Neighboring gene GrpE-like 1, mitochondrial Neighboring gene uncharacterized LOC134481854 Neighboring gene uncharacterized LOC134481853 Neighboring gene uncharacterized LOC134481778 Neighboring gene prosaposin-like 1 Neighboring gene actin filament associated protein 1 Neighboring gene uncharacterized LOC134481856 Neighboring gene uncharacterized LOC134481855

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SorCS2 is required for BDNF-dependent plasticity in the hippocampus. Glerup S, et al. Mol Psychiatry, 2016 Dec. PMID 27457814
    2. SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology. Malik AR, et al. Cell Rep, 2019 Mar 5. PMID 30840898, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-term synaptic depression ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    VPS10 domain-containing receptor SorCS2
    Names
    VPS10 domain receptor protein SORCS 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107225.2 → NP_001100695.2  VPS10 domain-containing receptor SorCS2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6IJY5
      Related
      ENSRNOP00000009960.8, ENSRNOT00000009960.9
      Conserved Domains (3) summary
      smart00602
      Location:170 → 776
      VPS10; VPS10 domain
      pfam00801
      Location:798 → 863
      PKD; PKD domain
      pfam15901
      Location:613 → 776
      Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      78592290..78960582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091958.2 → XP_038947886.1  VPS10 domain-containing receptor SorCS2 isoform X4

      Conserved Domains (1) summary
      smart00602
      Location:170 → 776
      VPS10; VPS10 domain

    2. XM_039091954.2 → XP_038947882.1  VPS10 domain-containing receptor SorCS2 isoform X1

      UniProtKB/TrEMBL
      A6IJY5, D3ZW09
      Conserved Domains (2) summary
      smart00602
      Location:170 → 776
      VPS10; VPS10 domain
      pfam00801
      Location:798 → 863
      PKD; PKD domain

    3. XM_039091957.2 → XP_038947885.1  VPS10 domain-containing receptor SorCS2 isoform X3

      UniProtKB/TrEMBL
      A6IJY5
      Conserved Domains (2) summary
      smart00602
      Location:1 → 604
      VPS10; VPS10 domain
      pfam00801
      Location:626 → 691
      PKD; PKD domain

    4. XM_039091956.2 → XP_038947884.1  VPS10 domain-containing receptor SorCS2 isoform X2

      UniProtKB/TrEMBL
      A6IJY5
      Conserved Domains (2) summary
      smart00602
      Location:70 → 676
      VPS10; VPS10 domain
      pfam00801
      Location:698 → 763
      PKD; PKD domain
    Nucleotide Protein Strain
    Heading Accession and Version

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