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    C6 complement C6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24237, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C6provided by RGD
    Official Full Name
    complement C6provided by RGD
    Primary source
    RGD:2238
    See related
    EnsemblRapid:ENSRNOG00000024115 AllianceGenome:RGD:2238
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Involved in positive regulation of apoptotic process. Located in extracellular space. Used to study end stage renal disease; glomerulonephritis; and proteinuria. Human ortholog(s) of this gene implicated in complement component 6 deficiency. Orthologous to human C6 (complement C6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 978.1) and Lung (RPKM 85.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q16
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (55573596..55648857)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (53846028..53921279)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (54460333..54533801)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-specific phospholipase C, X domain containing 3 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene septin 7, pseudogene 2 Neighboring gene maestro heat-like repeat family member 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inhibition of C5 or absence of C6 protects from sepsis mortality. Buras JA, et al. Immunobiology, 2004. PMID 15638131
    2. Depletion of C6 prevents development of proteinuria in experimental membranous nephropathy in rats. Baker PJ, et al. Am J Pathol, 1989 Jul. PMID 2672823, Free PMC Article
    3. Hepatic and extrahepatic biosynthesis of complement factor C6 in the rat. Brauer RB, et al. J Immunol, 1994 Oct 1. PMID 8089494
    4. C6 mediates chronic progression of tubulointerstitial damage in rats with remnant kidneys. Nangaku M, et al. J Am Soc Nephrol, 2002 Apr. PMID 11912252
    5. Attenuation of experimental allergic encephalomyelitis in complement component 6-deficient rats is associated with reduced complement C9 deposition, P-selectin expression, and cellular infiltrate in spinal cords. Tran GT, et al. J Immunol, 2002 May 1. PMID 11970970

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Findings suggest that C6 deficiency by itself does not alter the regrowth capacity of the peripheral nerve after crush injury.
      Title: C6 deficiency does not alter intrinsic regeneration speed after peripheral nerve crush injury.
    2. The present study thus defines a novel role for ASK1 as a mediator of C5b-9-dependent cell injury.
      Title: Role of apoptosis signal-regulating kinase 1 in complement-mediated glomerular epithelial cell injury.
    3. C6 deficiency did not lead to neuroprotection after status epilepticus
      Title: Complement protein 6 deficiency in PVG/c rats does not lead to neuroprotection against seizure induced cell death.
    4. Pathology showed improved nerve regeneration in tibials of C6 deficient animals compared to wildtypes.
      Title: Complement inhibition accelerates regeneration in a model of peripheral nerve injury.
    5. essential in the mechanism of hepatic ischemia/reperfusion injury
      Title: The membrane attack complex (C5b-9) in liver cold ischemia and reperfusion injury.
    6. This study demonstrates that complement component 6 is not essential for the development of proteinuria in passive Heymann nephritis.
      Title: Induction of passive Heymann nephritis in complement component 6-deficient PVG rats.
    7. The membrane attack complex of complement induces caspase activation and apoptosis.
      Title: The membrane attack complex of complement induces caspase activation and apoptosis.
    8. Lung allografts from C6-deficient donors to C6(-) recipients survive 13-17 days, whereas allografts from C6-sufficient donors to C6(+) recipients are rejected with intense vascular infiltration and diffuse alveolar hemorrhage 7 days posttransplant.
      Title: Membrane attack complex contributes to destruction of vascular integrity in acute lung allograft rejection.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in complement activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in complement activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in killing of cells of another organism IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of membrane attack complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of membrane attack complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane attack complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    complement component C6
    Names
    complement component 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176074.4 → NP_788263.2  complement component C6 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q811M5
      UniProtKB/TrEMBL
      F1M7F7
      Conserved Domains (8) summary
      cd00033
      Location:644 → 700
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02831
      Location:644 → 764
      PHA02831; EEV host range protein; Provisional
      smart00209
      Location:568 → 612
      TSP1; Thrombospondin type 1 repeats
      cd00112
      Location:142 → 173
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam01823
      Location:292 → 514
      MACPF; MAC/Perforin domain
      pfam19028
      Location:28 → 78
      TSP1_spondin; Spondin-like TSP1 domain
      cl15278
      Location:85 → 128
      TSP_1; Thrombospondin type 1 domain
      cl20168
      Location:862 → 934
      Kazal_3; Kazal-type serine protease inhibitor domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      55573596..55648857
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760747.4 → XP_008758969.2  complement component C6 isoform X1

      UniProtKB/Swiss-Prot
      Q811M5
      UniProtKB/TrEMBL
      F1M7F7
      Related
      ENSRNOP00000029891.5, ENSRNOT00000033112.6
      Conserved Domains (8) summary
      cd00033
      Location:644 → 700
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02831
      Location:644 → 764
      PHA02831; EEV host range protein; Provisional
      smart00209
      Location:568 → 612
      TSP1; Thrombospondin type 1 repeats
      cd00112
      Location:142 → 173
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam01823
      Location:292 → 514
      MACPF; MAC/Perforin domain
      pfam19028
      Location:28 → 78
      TSP1_spondin; Spondin-like TSP1 domain
      cl15278
      Location:85 → 128
      TSP_1; Thrombospondin type 1 domain
      cl20168
      Location:862 → 934
      Kazal_3; Kazal-type serine protease inhibitor domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q811M5.1 GenPept UniProtKB/Swiss-Prot:Q811M5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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