Hkdc1 hexokinase domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Hkdc1provided by RGD
Full Name: hexokinase domain containing 1provided by RGD
Primary source: RGD:2321830
See related: EnsemblRapid:ENSRNOG00000049045 AllianceGenome:RGD:2321830
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AABR07045032.1
Summary: Predicted to enable glucokinase activity. Predicted to be involved in glucose 6-phosphate metabolic process and intracellular glucose homeostasis. Predicted to be located in mitochondrion and photoreceptor inner segment. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human HKDC1 (hexokinase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 3.8), Brain (RPKM 2.8) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (30878037..30917044, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (30335322..30373792, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (32018027..32054494, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Integrated Multiomics Reveals Glucose Use Reprogramming and Identifies a Novel Hexokinase in Alcoholic Hepatitis.
Title: Integrated Multiomics Reveals Glucose Use Reprogramming and Identifies a Novel Hexokinase in Alcoholic Hepatitis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables D-glucose binding	IEA Inferred from Electronic Annotation more info
enables fructokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucokinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in carbohydrate phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in glucose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose 6-phosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular glucose homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular glucose homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hexokinase HKDC1; hexokinase domain containing 1

Names: hexokinase 1-like; putative hexokinase HKDC1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432154.1 → NP_001419083.1 hexokinase domain containing 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

M0R3X7
NM_001432155.1 → NP_001419084.1 hexokinase domain containing 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

30878037..30917044 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099162.2 → XP_038955090.1 hexokinase HKDC1 isoform X1

Related

ENSRNOP00000064051.3, ENSRNOT00000074989.4

Conserved Domains (3) summary

PTZ00107
Location:466 → 905

PTZ00107; hexokinase; Provisional

pfam00349
Location:21 → 219

Hexokinase_1

pfam03727
Location:225 → 459

Hexokinase_2
XM_039099165.2 → XP_038955093.1 hexokinase HKDC1 isoform X2

Conserved Domains (2) summary

PTZ00107
Location:228 → 667

PTZ00107; hexokinase; Provisional

pfam03727
Location:1 → 221

Hexokinase_2
XM_039099167.2 → XP_038955095.1 hexokinase HKDC1 isoform X3

Conserved Domains (2) summary

PTZ00107
Location:205 → 644

PTZ00107; hexokinase; Provisional

pfam03727
Location:31 → 198

Hexokinase_2