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    Slc2a9 solute carrier family 2 member 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501925, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc2a9provided by RGD
    Official Full Name
    solute carrier family 2 member 9provided by RGD
    Primary source
    RGD:1597012
    See related
    EnsemblRapid:ENSRNOG00000005302 AllianceGenome:RGD:1597012
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable D-glucose transmembrane transporter activity; fructose transmembrane transporter activity; and urate transmembrane transporter activity. Predicted to be involved in fructose transmembrane transport; urate metabolic process; and urate transport. Predicted to act upstream of or within D-glucose transmembrane transport. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Predicted to be active in plasma membrane. Orthologous to human SLC2A9 (solute carrier family 2 member 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 126.4), Kidney (RPKM 45.6) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc2a9 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (76540649..76674277)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (72328334..72461981)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (77067537..77192702)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene serine/arginine-rich splicing factor 3 pseudogene Neighboring gene uncharacterized LOC134481771 Neighboring gene WD repeat domain 1 Neighboring gene dopamine receptor D5 Neighboring gene otopetrin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9. DeBosch BJ, et al. Nat Commun, 2014 Aug 7. PMID 25100214, Free PMC Article
    2. Mouse GLUT9: evidences for a urate uniporter. Bibert S, et al. Am J Physiol Renal Physiol, 2009 Sep. PMID 19587147
    3. SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Vitart V, et al. Nat Genet, 2008 Apr. PMID 18327257
    4. GLUT9 is differentially expressed and targeted in the preimplantation embryo. Carayannopoulos MO, et al. Endocrinology, 2004 Mar. PMID 14657010
    5. Renal Reabsorptive Transport of Uric Acid Precursor Xanthine by URAT1 and GLUT9. Arakawa H, et al. Biol Pharm Bull, 2020. PMID 33132325

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Renal Reabsorptive Transport of Uric Acid Precursor Xanthine by URAT1 and GLUT9.
      Title: Renal Reabsorptive Transport of Uric Acid Precursor Xanthine by URAT1 and GLUT9.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables D-glucose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables D-glucose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables fructose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fructose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables urate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glucose import IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in D-glucose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within D-glucose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in D-glucose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dehydroascorbic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in fructose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fructose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in urate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in urate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 2, facilitated glucose transporter member 9
    Names
    solute carrier family 2 (facilitated glucose transporter), member 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191551.1 → NP_001178480.1  solute carrier family 2, facilitated glucose transporter member 9

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6IJT3, D4A237
      Related
      ENSRNOP00000045713.2, ENSRNOT00000042200.4
      Conserved Domains (2) summary
      cd06174
      Location:49 → 486
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:47 → 502
      Sugar_tr; Sugar (and other) transporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      76540649..76674277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273504.1 → XP_063129574.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JW25
      Related
      ENSRNOP00000103826.1, ENSRNOT00000141839.1

    2. XM_039092336.2 → XP_038948264.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JW25, A0A8I6AVN8
      Related
      ENSRNOP00000097928.1, ENSRNOT00000110037.2
      Conserved Domains (1) summary
      cd17432
      Location:47 → 498
      MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

    3. XM_006251100.4 → XP_006251162.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X2

      See identical proteins and their annotated locations for XP_006251162.1

      UniProtKB/TrEMBL
      A0A0G2JW25
      Related
      ENSRNOP00000083445.2, ENSRNOT00000099469.2
      Conserved Domains (2) summary
      cd06174
      Location:27 → 464
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:25 → 480
      Sugar_tr; Sugar (and other) transporter

    4. XM_006251101.5 → XP_006251163.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X2

      See identical proteins and their annotated locations for XP_006251163.1

      UniProtKB/TrEMBL
      A0A0G2JW25
      Conserved Domains (2) summary
      cd06174
      Location:27 → 464
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:25 → 480
      Sugar_tr; Sugar (and other) transporter

    5. XM_063273505.1 → XP_063129575.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X5

      UniProtKB/TrEMBL
      A6IJT3

    6. XM_006251102.5 → XP_006251164.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X3

      UniProtKB/TrEMBL
      A0A8I6G921, A6IJT3
      Conserved Domains (2) summary
      cd06174
      Location:49 → 452
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:47 → 468
      Sugar_tr; Sugar (and other) transporter
    Nucleotide Protein Strain
    Heading Accession and Version

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