Hspa4l heat shock protein family A (Hsp70) member 4 like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hspa4lprovided by RGD
Official Full Name: heat shock protein family A (Hsp70) member 4 likeprovided by RGD
Primary source: RGD:1306528
See related: EnsemblRapid:ENSRNOG00000010819 AllianceGenome:RGD:1306528
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: APG-1; OSP94
Summary: Enables ATP binding activity. Involved in protein folding and response to unfolded protein. Located in cytoplasm and nucleus. Orthologous to human HSPA4L (heat shock protein family A (Hsp70) member 4 like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 306.2), Brain (RPKM 225.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q26

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (125668346..125726404)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (123740384..123793088)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (127625737..127682864)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

characterization of the biochemical properties of the testis and brain-specific 105-kDa protein [105-kDa molecular chaperone (APG-1/OSP94)]
Title: Characterization of the 105-kDa molecular chaperone. Identification, biochemical properties, and localization.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:498266 (e-PCR)
- UniSTS:498266

Hspa4l (e-PCR), detects polymorphism
- UniSTS:498266

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein folding	IDA Inferred from Direct Assay more info	PubMed
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in response to unfolded protein	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heat shock 70 kDa protein 4L

Names: heat shock 70-related protein APG-1; heat shock 70kDa protein 4-like; heat shock protein 4-like; osmotic stress protein 94

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106428.2 → NP_001099898.2 heat shock 70 kDa protein 4L

See identical proteins and their annotated locations for NP_001099898.2

Status: VALIDATED

Source sequence(s)

BC168157

UniProtKB/TrEMBL

B4F772, F7F2F3

Related

ENSRNOP00000015474.6, ENSRNOT00000015474.8

Conserved Domains (1) summary

cd11738
Location:2 → 384

HSPA4L_NBD; Nucleotide-binding domain of HSPA4L

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

125668346..125726404

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102005.2 → XP_038957933.1 heat shock 70 kDa protein 4L isoform X1

UniProtKB/TrEMBL

B4F772, F7F2F3

Conserved Domains (1) summary

cd11738
Location:2 → 384

HSPA4L_NBD; Nucleotide-binding domain of HSPA4L