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    Rnf122 ring finger protein 122 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502091, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf122provided by RGD
    Official Full Name
    ring finger protein 122provided by RGD
    Primary source
    RGD:1561238
    See related
    EnsemblRapid:ENSRNOG00000023473 AllianceGenome:RGD:1561238
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561238
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of mitochondrial membrane potential; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein autoubiquitination. Predicted to be located in cytoplasm. Orthologous to human RNF122 (ring finger protein 122). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 93.7), Heart (RPKM 74.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnf122 in Genome Data Viewer
    Location:
    16q12.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (67712936..67730479, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (61009879..61027429, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (64766878..64787308, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene MAK16 homolog Neighboring gene TELO2 interacting protein 2 Neighboring gene small nucleolar RNA, C/D box 13 Neighboring gene uncharacterized LOC134482403 Neighboring gene dual specificity phosphatase 26 Neighboring gene uncharacterized LOC120097498

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RNF122: a novel ubiquitin ligase associated with calcium-modulating cyclophilin ligand. Peng Z, et al. BMC Cell Biol, 2010 Jun 17. PMID 20553626, Free PMC Article
    2. Cell-based screening and validation of human novel genes associated with cell viability. Wang L, et al. J Biomol Screen, 2006 Jun. PMID 16751333
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RING finger protein 122

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399271.1 → NP_001386200.1  RING finger protein 122 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      Related
      ENSRNOP00000037851.7, ENSRNOT00000031701.8
      Conserved Domains (1) summary
      cd16469
      Location:91 → 137
      RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

    2. NM_001399272.1 → NP_001386201.1  RING finger protein 122 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6AJB0
      Related
      ENSRNOP00000088658.1, ENSRNOT00000116029.2
      Conserved Domains (1) summary
      cd16469
      Location:119 → 165
      RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      67712936..67730479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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