Acad9 acyl-CoA dehydrogenase family, member 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acad9provided by RGD
Official Full Name: acyl-CoA dehydrogenase family, member 9provided by RGD
Primary source: RGD:727973
See related: EnsemblRapid:ENSRNOG00000014178 AllianceGenome:RGD:727973
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ACAD-9; Nyggf2
Summary: Predicted to enable long-chain fatty acyl-CoA dehydrogenase activity and medium-chain fatty acyl-CoA dehydrogenase activity. Predicted to be involved in long-chain fatty acid metabolic process; medium-chain fatty acid metabolic process; and mitochondrial respiratory chain complex I assembly. Predicted to be located in dendrite; mitochondrial membrane; and nucleus. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 20. Orthologous to human ACAD9 (acyl-CoA dehydrogenase family member 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 205.3), Adrenal (RPKM 134.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q25

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (120871329..120894306)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (118943170..118966150)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (122782051..122806166)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results suggested that Glu389 could function as the catalytic base that abstracted the alpha-proton of the acyl-CoA substrate in a proposed catalytic mechanism.
Title: Identification of the Catalytic Residue of Rat Acyl-CoA Dehydrogenase 9 by Site-Directed Mutagenesis.
Accumulation of 3-hydroxylated intermediates of long-chain fatty acids may contribute to the pathogenesis of retinopathy in MTP deficiencies.
Title: Carnitine palmitoyltransferase I and Acyl-CoA dehydrogenase 9 in retina: insights of retinopathy in mitochondrial trifunctional protein defects.

Submit: New GeneRIF Correction

General gene information

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Markers

AI178764 (e-PCR)
- UniSTS:261167

RH136888 (e-PCR)
- UniSTS:218977

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acyl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acyl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables medium-chain fatty acyl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in carboxylic acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in medium-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complex I assembly factor ACAD9, mitochondrial

Names: acyl-CoA dehydrogenase family member 9, mitochondrial; acyl-Coenzyme A dehydrogenase family, member 9

NP_861433.2

EC 1.3.8.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181768.2 → NP_861433.2 complex I assembly factor ACAD9, mitochondrial

See identical proteins and their annotated locations for NP_861433.2

Status: PROVISIONAL

Source sequence(s)

BC162016

UniProtKB/Swiss-Prot

B1WC61

UniProtKB/TrEMBL

A6IHW4

Related

ENSRNOP00000070329.1, ENSRNOT00000089353.3

Conserved Domains (1) summary

cd01161
Location:42 → 449

VLCAD; Very long chain acyl-CoA dehydrogenase