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    Cpz carboxypeptidase Z [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83575, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cpzprovided by RGD
    Official Full Name
    carboxypeptidase Zprovided by RGD
    Primary source
    RGD:620496
    See related
    EnsemblRapid:ENSRNOG00000008947 AllianceGenome:RGD:620496
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to be active in extracellular space. Orthologous to human CPZ (carboxypeptidase Z). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 52.1), Lung (RPKM 46.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cpz in Genome Data Viewer
    Location:
    14q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (79448242..79471557)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (75223692..75246946)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (80402946..80426203)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene HtrA serine peptidase 3 Neighboring gene acyl-CoA oxidase 3, pristanoyl Neighboring gene tRNA methyltransferase 44 Neighboring gene uncharacterized LOC120096640 Neighboring gene H6 family homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning, sequence analysis, and distribution of rat metallocarboxypeptidase Z. Xin X, et al. DNA Cell Biol, 1998 Apr. PMID 9570147
    2. Carboxypeptidase Z (CPZ) links thyroid hormone and Wnt signaling pathways in growth plate chondrocytes. Wang L, et al. J Bone Miner Res, 2009 Feb. PMID 18847325, Free PMC Article
    3. Genomic analysis of alachlor-induced oncogenesis in rat olfactory mucosa. Genter MB, et al. Physiol Genomics, 2002 Dec 26. PMID 12419858
    4. Metallocarboxypeptidase Z is dynamically expressed in mouse development. Novikova E, et al. Mech Dev, 2001 Apr. PMID 11287206
    5. Carboxypeptidase Z is present in the regulated secretory pathway and extracellular matrix in cultured cells and in human tissues. Novikova EG, et al. J Biol Chem, 2000 Feb 18. PMID 10671522

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carboxypeptidase Z

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031766.1 → NP_113954.1  carboxypeptidase Z precursor

      See identical proteins and their annotated locations for NP_113954.1

      Status: PROVISIONAL

      Source sequence(s)
      AF017637
      UniProtKB/Swiss-Prot
      O54858, O54859
      UniProtKB/TrEMBL
      A0A0G2JSJ7, A6IJZ7
      Related
      ENSRNOP00000012109.3, ENSRNOT00000012109.6
      Conserved Domains (3) summary
      cd03867
      Location:190 → 504
      M14_CPZ; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase Z subgroup
      cd11308
      Location:508 → 584
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      cl02447
      Location:43 → 170
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      79448242..79471557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273680.1 → XP_063129750.1  carboxypeptidase Z isoform X3

    2. XM_006251151.5 → XP_006251213.1  carboxypeptidase Z isoform X2

      UniProtKB/TrEMBL
      A0A0G2JSJ7, A0A8I6A134, A6IJZ7
      Related
      ENSRNOP00000085858.1, ENSRNOT00000113023.2
      Conserved Domains (3) summary
      cd03867
      Location:179 → 493
      M14_CPZ; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase Z subgroup
      cd11308
      Location:497 → 573
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      cl02447
      Location:32 → 159
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

    3. XM_063273679.1 → XP_063129749.1  carboxypeptidase Z isoform X1

      UniProtKB/TrEMBL
      A0A8I6GLC7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54858.1 GenPept UniProtKB/Swiss-Prot:O54858

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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