Qdpr quinoid dihydropteridine reductase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Qdprprovided by RGD
Official Full Name: quinoid dihydropteridine reductaseprovided by RGD
Primary source: RGD:619915
See related: EnsemblRapid:ENSRNOG00000003253 AllianceGenome:RGD:619915
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables 6,7-dihydropteridine reductase activity; adenyl nucleotide binding activity; and identical protein binding activity. Involved in several processes, including L-phenylalanine catabolic process; response to glucagon; and tetrahydrobiopterin biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Biomarker of hypertension and status epilepticus. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia C and phenylketonuria. Orthologous to human QDPR (quinoid dihydropteridine reductase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 354.5), Kidney (RPKM 327.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (69882776..69896378)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (65670251..65683853)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (70164682..70178284)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that intrauterine growth restriction increases serotonin biosynthesis in the brainstem, which is accompanied by an increase in dihydropteridine reductase activity that may be a compensatory mechanism to maintain sufficient tetrahydrobiopterin.
Title: Dihydropteridine reductase activity in the brainstem of intrauterine growth-restricted rats.
results suggest that the deficiency in tetrahydrobiopterin regeneration produced by diminished dihydrobiopterin reductase expression is involved in vascular disorders in hypertensive rats.
Title: Diminished expression of dihydropteridine reductase is a potent biomarker for hypertensive vessels.

Submit: New GeneRIF Correction

General gene information

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Markers

RH127087 (e-PCR)
- UniSTS:167431

RH140863 (e-PCR)
- UniSTS:222891

RH142413 (e-PCR)
- UniSTS:231660

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 6,7-dihydropteridine reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 6,7-dihydropteridine reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables 6,7-dihydropteridine reductase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 6,7-dihydropteridine reductase activity	ISO Inferred from Sequence Orthology more info
enables NADH binding	IBA Inferred from Biological aspect of Ancestor more info
enables NADH binding	IPI Inferred from Physical Interaction more info	PubMed
enables NADPH binding	IBA Inferred from Biological aspect of Ancestor more info
enables NADPH binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-phenylalanine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-phenylalanine catabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to aluminum ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucagon	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in tetrahydrobiopterin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tetrahydrobiopterin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in tetrahydrobiopterin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in tetrahydrobiopterin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tetrahydrobiopterin biosynthetic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: dihydropteridine reductase

Names: HDHPR

NP_071785.1

EC 1.5.1.34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.