Upk1a uroplakin 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Upk1aprovided by MGI
Official Full Name: uroplakin 1Aprovided by MGI
Primary source: MGI:MGI:98911
See related: Ensembl:ENSMUSG00000006313 AllianceGenome:MGI:98911
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Upk1; Tspan21; 1110031P12Rik
Summary: Predicted to be involved in epithelial cell differentiation. Located in apical plasma membrane. Is active in apical plasma membrane urothelial plaque. Is expressed in heart ventricle; lower urinary tract; lung; and rectum. Orthologous to human UPK1A (uroplakin 1A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 983.6), ovary adult (RPKM 86.0) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 18.78 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (30302517..30312159, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (30603092..30612734, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Uroplakin 1a Knockout Mice Display Marginal Reduction in Fecundity, Decreased Bacterial Clearance Capacity, and Drastic Changes in the Testicular Transcriptome.
Title: Uroplakin 1a Knockout Mice Display Marginal Reduction in Fecundity, Decreased Bacterial Clearance Capacity, and Drastic Changes in the Testicular Transcriptome.
mouse urothelium responds to the adhesion of type 1-fimbriated UPEC by activating dual ligand/receptor system, one between FimH adhesin and uroplakin Ia and another between lipopolysaccharide and Tlr4.
Title: Dual ligand/receptor interactions activate urothelial defenses against uropathogenic E. coli.
These data support a model in which SNX31 mediates the endocytic degradation of uroplakins.
Title: SNX31: a novel sorting nexin associated with the uroplakin-degrading multivesicular bodies in terminally differentiated urothelial cells.
The despites a lower level of expression, UPIa maintain its plaque association in urothelial preneoplastic lesions.
Title: Expression and localization of four uroplakins in urothelial preneoplastic lesions.
Localization of uroplakin Ia, the urothelial receptor for bacterial adhesin FimH, on the six inner domains of the 16 nm urothelial plaque particle
Title: Localization of uroplakin Ia, the urothelial receptor for bacterial adhesin FimH, on the six inner domains of the 16 nm urothelial plaque particle.
structure of the major membrane protein complex from urinary bladder epithelial cells by cryo-electron crystallography
Title: Structure of the major membrane protein complex from urinary bladder epithelial cells by cryo-electron crystallography.
analysis of glycan structures of uroplakins Ia and Ib
Title: Distinct glycan structures of uroplakins Ia and Ib: structural basis for the selective binding of FimH adhesin to uroplakin Ia.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Gene trapped (1)

General gene information

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Markers

RH136475 (e-PCR)
- UniSTS:210460

NoName (e-PCR)
- UniSTS:492190

Upk1a (e-PCR), detects polymorphism
- UniSTS:527016

C87192 (e-PCR)
- UniSTS:208105

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical plasma membrane urothelial plaque	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: uroplakin-1a

Names: UP1a; UPIa; UPKa; uroplakin Ia

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026815.2 → NP_081091.1 uroplakin-1a

See identical proteins and their annotated locations for NP_081091.1

Status: PROVISIONAL

Source sequence(s)

AK004014

Consensus CDS

CCDS21103.1

UniProtKB/Swiss-Prot

Q9D132

UniProtKB/TrEMBL

A2RSB9

Related

ENSMUSP00000006476.5, ENSMUST00000006476.6

Conserved Domains (1) summary

cd03156
Location:111 → 229

uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...