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    Rbm12b2 RNA binding motif protein 12 B2 [ Mus musculus (house mouse) ]

    Gene ID: 77604, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbm12b2provided by MGI
    Official Full Name
    RNA binding motif protein 12 B2provided by MGI
    Primary source
    MGI:MGI:1924854
    See related
    Ensembl:ENSMUSG00000052137 AllianceGenome:MGI:1924854
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rbm12bb; C430048L16Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Orthologous to human RBM12B (RNA binding motif protein 12B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 9.6), CNS E14 (RPKM 9.2) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rbm12b2 in Genome Data Viewer
    Location:
    4 A1; 4 5.58 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (12089370..12105618)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (12089370..12105618)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46844 Neighboring gene STARR-seq mESC enhancer starr_09607 Neighboring gene STARR-seq mESC enhancer starr_09608 Neighboring gene transmembrane protein 67 Neighboring gene predicted gene, 52723 Neighboring gene STARR-positive B cell enhancer ABC_E2104 Neighboring gene STARR-positive B cell enhancer ABC_E2686 Neighboring gene STARR-seq mESC enhancer starr_09609 Neighboring gene poly A binding protein, cytoplasmic 4 pseudogene Neighboring gene poly A binding protein, cytoplasmic 4 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC91091

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 12B-B
    Names
    RNA-binding motif protein 12B-B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356562.1 → NP_001343491.1  RNA-binding protein 12B-B

      Status: VALIDATED

      Source sequence(s)
      AK080943, AL772167, BB653094, BC080741, BY620336, CJ158172
      Consensus CDS
      CCDS17975.1
      UniProtKB/Swiss-Prot
      A2AJP4, Q3TE05, Q66JV4, Q8BNP2, Q8K0T9
      UniProtKB/TrEMBL
      B2RPV4
      Related
      ENSMUSP00000092765.3, ENSMUST00000095143.9
      Conserved Domains (5) summary
      PTZ00465
      Location:590 → 690
      PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
      COG0724
      Location:367 → 562
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12746
      Location:152 → 237
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:401 → 476
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cl17169
      Location:2 → 80
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001356563.1 → NP_001343492.1  RNA-binding protein 12B-B

      Status: VALIDATED

      Source sequence(s)
      AK080943, AL772167, BB653094, BC080741, BY152564, BY620336, CJ158172
      Consensus CDS
      CCDS17975.1
      UniProtKB/Swiss-Prot
      A2AJP4, Q3TE05, Q66JV4, Q8BNP2, Q8K0T9
      UniProtKB/TrEMBL
      B2RPV4
      Conserved Domains (5) summary
      PTZ00465
      Location:590 → 690
      PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
      COG0724
      Location:367 → 562
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12746
      Location:152 → 237
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:401 → 476
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cl17169
      Location:2 → 80
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_198957.2 → NP_945195.1  RNA-binding protein 12B-B

      See identical proteins and their annotated locations for NP_945195.1

      Status: VALIDATED

      Source sequence(s)
      AK080943, BB653094, BC080741, BY620336, CJ179945
      Consensus CDS
      CCDS17975.1
      UniProtKB/Swiss-Prot
      A2AJP4, Q3TE05, Q66JV4, Q8BNP2, Q8K0T9
      UniProtKB/TrEMBL
      B2RPV4
      Related
      ENSMUSP00000066311.6, ENSMUST00000063839.6
      Conserved Domains (5) summary
      PTZ00465
      Location:590 → 690
      PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
      COG0724
      Location:367 → 562
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12746
      Location:152 → 237
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:401 → 476
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cl17169
      Location:2 → 80
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      12089370..12105618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320453.3 → XP_017175942.1  RNA-binding protein 12B-B isoform X1

      UniProtKB/Swiss-Prot
      A2AJP4, Q3TE05, Q66JV4, Q8BNP2, Q8K0T9
      UniProtKB/TrEMBL
      B2RPV4
      Conserved Domains (5) summary
      PTZ00465
      Location:590 → 690
      PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
      COG0724
      Location:367 → 562
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12746
      Location:152 → 237
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:401 → 476
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cl17169
      Location:2 → 80
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_036164545.1 → XP_036020438.1  RNA-binding protein 12B-B isoform X1

      UniProtKB/Swiss-Prot
      A2AJP4, Q3TE05, Q66JV4, Q8BNP2, Q8K0T9
      UniProtKB/TrEMBL
      B2RPV4
      Conserved Domains (5) summary
      PTZ00465
      Location:590 → 690
      PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
      COG0724
      Location:367 → 562
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12746
      Location:152 → 237
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:401 → 476
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cl17169
      Location:2 → 80
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66JV4.2 GenPept UniProtKB/Swiss-Prot:Q66JV4

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