Tppp2 tubulin polymerization-promoting protein family member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tppp2provided by MGI
Official Full Name: tubulin polymerization-promoting protein family member 2provided by MGI
Primary source: MGI:MGI:2684923
See related: Ensembl:ENSMUSG00000008813 AllianceGenome:MGI:2684923
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm77; Gm1790
Summary: Predicted to enable tubulin binding activity. Involved in regulation of flagellated sperm motility. Located in sperm flagellum. Orthologous to human TPPP2 (tubulin polymerization promoting protein family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 47.4) See more
Orthologs: human all
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Genomic context

Location:: 14 C2; 14 26.72 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (52155887..52158161)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (51918430..51920704)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of TPPP2 might affect the translation of specific proteins, such as eEf1b, altering the structure and function of sperm mitochondria, and resulting in decreased sperm count, motility and fertility.
Title: Deficiency of TPPP2, a factor linked to oligoasthenozoospermia, causes subfertility in male mice.
Foxo3 represses ROS in part via regulation of ATM and this repression is required for maintenance of the hematopoietic stem cell pool
Title: Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin binding	IEA Inferred from Electronic Annotation more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in microtubule bundle formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule polymerization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
colocalizes_with microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tubulin polymerization-promoting protein family member 2

Names: p25 beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128634.1 → NP_001122106.1 tubulin polymerization-promoting protein family member 2

Status: VALIDATED

Source sequence(s)

BC049709

Consensus CDS

CCDS49487.1

UniProtKB/Swiss-Prot

Q0P5Y3

Related

ENSMUSP00000136454.2, ENSMUST00000177625.2

Conserved Domains (1) summary

pfam05517
Location:6 → 161

p25-alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

52155887..52158161

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006518844.4 → XP_006518907.1 tubulin polymerization-promoting protein family member 2 isoform X1

UniProtKB/Swiss-Prot

Q0P5Y3

Related

ENSMUSP00000008957.6, ENSMUST00000008957.13

Conserved Domains (1) summary

pfam05517
Location:6 → 161

p25-alpha