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    Slc9a5 solute carrier family 9 (sodium/hydrogen exchanger), member 5 [ Mus musculus (house mouse) ]

    Gene ID: 277973, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc9a5provided by MGI
    Official Full Name
    solute carrier family 9 (sodium/hydrogen exchanger), member 5provided by MGI
    Primary source
    MGI:MGI:2685542
    See related
    Ensembl:ENSMUSG00000014786 AllianceGenome:MGI:2685542
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm696; NHE-5
    Summary
    Predicted to enable arrestin family protein binding activity; potassium:proton antiporter activity; and sodium:proton antiporter activity. Predicted to be involved in monoatomic cation transmembrane transport and regulation of intracellular pH. Predicted to be located in several cellular components, including focal adhesion; neuron spine; and recycling endosome membrane. Predicted to be active in plasma membrane. Is expressed in brain. Human ortholog(s) of this gene implicated in end stage renal disease. Orthologous to human SLC9A5 (solute carrier family 9 member A5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 13.3), limb E14.5 (RPKM 12.5) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc9a5 in Genome Data Viewer
    Location:
    8 D3; 8 53.04 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106074782..106095979)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105348156..105369881)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11746 Neighboring gene transmembrane protein 208 Neighboring gene formin homology 2 domain containing 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:107871965-107872074 Neighboring gene predicted gene, 46049 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 4 Neighboring gene potassium channel tetramerisation domain containing 19 Neighboring gene leucine rich repeat containing 36

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nhe5 deficiency enhances learning and memory via upregulating Bdnf/TrkB signaling in mice. Chen X, et al. Am J Med Genet B Neuropsychiatr Genet, 2017 Dec. PMID 28981195
    2. The Na(+)/H (+) exchanger NHE5 is sorted to discrete intracellular vesicles in the central and peripheral nervous systems. Lukashova V, et al. Adv Exp Med Biol, 2013. PMID 23224898
    3. Activation of AMP-activated protein kinase regulates hippocampal neuronal pH by recruiting Na(+)/H(+) exchanger NHE5 to the cell surface. Jinadasa T, et al. J Biol Chem, 2014 Jul 25. PMID 24936055, Free PMC Article
    4. NHE1 is the sodium-hydrogen exchanger active in acute intracellular pH regulation in preimplantation mouse embryos. Siyanov V, et al. Biol Reprod, 2013 Jun. PMID 23677982
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nhe5 deficiency is associated with enhanced learning and memory by upregulating Bdnf and TrkB signaling.
      Title: Nhe5 deficiency enhances learning and memory via upregulating Bdnf/TrkB signaling in mice.
    2. These data reveal a unique role for AMPK and NHE5 in regulating the pH homeostasis of hippocampal neurons during metabolic stress.
      Title: Activation of AMP-activated protein kinase regulates hippocampal neuronal pH by recruiting Na(+)/H(+) exchanger NHE5 to the cell surface.
    3. NHE5 partitions into a unique vesicular pool in neurons that shares some characteristics of recycling endosomes where it may serve as an important regulated store of functional transporters required to maintain cytoplasmic pH homeostasis.
      Title: The Na(+)/H (+) exchanger NHE5 is sorted to discrete intracellular vesicles in the central and peripheral nervous systems.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arrestin family protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arrestin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium:proton antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of intracellular pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of intracellular pH ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sodium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in dendritic spine membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in neuron spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron spine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    sodium/hydrogen exchanger 5
    Names
    Na(+)/H(+) exchanger 5
    sodium/hydrogen exchanger
    solute carrier family 9 member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081332.2 → NP_001074801.1  sodium/hydrogen exchanger 5 precursor

      See identical proteins and their annotated locations for NP_001074801.1

      Status: VALIDATED

      Source sequence(s)
      AC124584
      Consensus CDS
      CCDS40457.1
      UniProtKB/Swiss-Prot
      B2RXE2
      Related
      ENSMUSP00000072893.6, ENSMUST00000073149.7
      Conserved Domains (2) summary
      TIGR00840
      Location:44 → 633
      b_cpa1; sodium/hydrogen exchanger 3
      pfam00999
      Location:53 → 458
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    RNA

    1. NR_175833.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124584

    2. NR_175834.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124584

    3. NR_175835.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124584

    4. NR_175836.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124584

    5. NR_175837.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124584

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106074782..106095979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531067.5 → XP_006531130.1  sodium/hydrogen exchanger 5 isoform X4

      Conserved Domains (1) summary
      TIGR00840
      Location:5 → 649
      b_cpa1; sodium/hydrogen exchanger 3

    2. XM_006531064.4 → XP_006531127.1  sodium/hydrogen exchanger 5 isoform X1

      Conserved Domains (1) summary
      TIGR00840
      Location:44 → 706
      b_cpa1; sodium/hydrogen exchanger 3

    3. XM_006531065.4 → XP_006531128.1  sodium/hydrogen exchanger 5 isoform X2

      Conserved Domains (1) summary
      TIGR00840
      Location:44 → 706
      b_cpa1; sodium/hydrogen exchanger 3

    4. XM_006531066.4 → XP_006531129.1  sodium/hydrogen exchanger 5 isoform X3

      Conserved Domains (1) summary
      TIGR00840
      Location:44 → 670
      b_cpa1; sodium/hydrogen exchanger 3

    5. XM_017312849.3 → XP_017168338.1  sodium/hydrogen exchanger 5 isoform X5

      Conserved Domains (1) summary
      TIGR00840
      Location:44 → 633
      b_cpa1; sodium/hydrogen exchanger 3

    6. XM_006531069.2 → XP_006531132.1  sodium/hydrogen exchanger 5 isoform X6

      Conserved Domains (1) summary
      TIGR00840
      Location:1 → 408
      b_cpa1; sodium/hydrogen exchanger 3

    RNA

    1. XR_387750.4 RNA Sequence

    2. XR_003947300.2 RNA Sequence

    3. XR_004934839.1 RNA Sequence

    4. XR_003947302.2 RNA Sequence

    5. XR_003947303.2 RNA Sequence

    6. XR_004934838.1 RNA Sequence

    7. XR_003947298.2 RNA Sequence

    8. XR_387749.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RXE2.1 GenPept UniProtKB/Swiss-Prot:B2RXE2

    Gene LinkOut

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