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    Rnf212 ring finger protein 212 [ Mus musculus (house mouse) ]

    Gene ID: 671564, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf212provided by MGI
    Official Full Name
    ring finger protein 212provided by MGI
    Primary source
    MGI:MGI:3645767
    See related
    Ensembl:ENSMUSG00000055385 AllianceGenome:MGI:3645767
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    repro57; EG330157; F830003B07
    Summary
    Predicted to enable SUMO transferase activity. Involved in chiasma assembly and meiotic gene conversion. Colocalizes with synaptonemal complex. Human ortholog(s) of this gene implicated in spermatogenic failure 62. Orthologous to human RNF212 (ring finger protein 212). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 2.5), colon adult (RPKM 0.7) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf212 in Genome Data Viewer
    Location:
    5 F; 5 53.24 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108875971..108922933, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108728105..108775067, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene iduronidase, alpha-L Neighboring gene predicted gene, 42151 Neighboring gene fibroblast growth factor receptor-like 1 Neighboring gene RIKEN cDNA 1700047L14 gene Neighboring gene 40S ribosomal protein S8 pseudogene Neighboring gene transmembrane p24 trafficking protein 11 Neighboring gene vomeronasal 2, receptor 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An ENU-induced mutation in the mouse Rnf212 gene is associated with male meiotic failure and infertility. Fujiwara Y, et al. Reproduction, 2015 Jan. PMID 25342176, Free PMC Article
    2. A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination. Rao HB, et al. Science, 2017 Jan 27. PMID 28059716, Free PMC Article
    3. Impeding DNA Break Repair Enables Oocyte Quality Control. Qiao H, et al. Mol Cell, 2018 Oct 18. PMID 30270110, Free PMC Article
    4. Genetics of Genome-Wide Recombination Rate Evolution in Mice from an Isolated Island. Wang RJ, et al. Genetics, 2017 Aug. PMID 28576862, Free PMC Article
    5. Interplay between synaptonemal complex, homologous recombination, and centromeres during mammalian meiosis. Qiao H, et al. PLoS Genet, 2012 Jun. PMID 22761591, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interdependent localization of SUMO, ubiquitin, and proteasomes along chromosome axes was mediated largely by RNF212 and HEI10, two E3 ligases that are also essential for crossover recombination.
      Title: A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination.
    2. Mutation in the mouse Rnf212 gene is associated with male meiotic failure and infertility.
      Title: An ENU-induced mutation in the mouse Rnf212 gene is associated with male meiotic failure and infertility.
    3. Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination.
      Title: Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination.
    4. We show that mouse RNF212 is essential for crossing-over, functioning to couple chromosome synapsis to the formation of crossover-specific recombination complexes
      Title: RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO transferase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables SUMO transferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chiasma assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homologous chromosome pairing at meiosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic gene conversion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein sumoylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein sumoylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    probable E3 SUMO-protein ligase RNF212
    Names
    probable E3 SUMO-protein transferase RNF212

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362887.1 → NP_001349816.1  probable E3 SUMO-protein ligase RNF212

      Status: VALIDATED

      Source sequence(s)
      AC123743
      Consensus CDS
      CCDS89962.1
      UniProtKB/Swiss-Prot
      F6TQD1, Q8BN46
      Related
      ENSMUSP00000148758.2, ENSMUST00000212212.2
      Conserved Domains (3) summary
      PHA03247
      Location:148 → 300
      PHA03247; large tegument protein UL36; Provisional
      COG4098
      Location:6 → 113
      comFA; Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [Replication, recombination and repair]
      cd16746
      Location:4 → 50
      RING-HC_RNF212; RING finger, HC subclass, found in RING finger protein 212 (RNF212) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      108875971..108922933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535331.4 → XP_006535394.1  probable E3 SUMO-protein ligase RNF212 isoform X1

      Conserved Domains (4) summary
      PHA03247
      Location:148 → 300
      PHA03247; large tegument protein UL36; Provisional
      COG4098
      Location:6 → 113
      comFA; Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [Replication, recombination and repair]
      cd00162
      Location:7 → 45
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl17238
      Location:4 → 50
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_006535332.3 → XP_006535395.1  probable E3 SUMO-protein ligase RNF212 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JDH3
      Related
      ENSMUSP00000142368.2, ENSMUST00000197384.5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F6TQD1.3 GenPept UniProtKB/Swiss-Prot:F6TQD1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials