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    Muc1 mucin 1, transmembrane [ Mus musculus (house mouse) ]

    Gene ID: 17829, updated on 9-Dec-2024

    Summary

    Official Symbol
    Muc1provided by MGI
    Official Full Name
    mucin 1, transmembraneprovided by MGI
    Primary source
    MGI:MGI:97231
    See related
    Ensembl:ENSMUSG00000042784 AllianceGenome:MGI:97231
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EMA; CD227; Muc-1
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; p53 binding activity; and transcription coregulator activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and regulation of DNA-templated transcription. Located in apical plasma membrane and cell surface. Is expressed in several structures, including alimentary system; brain; exocrine system; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including allergic rhinitis; biliary tract benign neoplasm; dry eye syndrome; familial juvenile hyperuricemic nephropathy; and pancreatic cancer (multiple). Orthologous to human MUC1 (mucin 1, cell surface associated). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in stomach adult (RPKM 255.6), lung adult (RPKM 94.3) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Muc1 in Genome Data Viewer
    Location:
    3 F1; 3 39.02 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89136363..89140688)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89229056..89233381)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene thrombospondin 3 Neighboring gene STARR-seq mESC enhancer starr_08226 Neighboring gene predicted gene, 57704 Neighboring gene STARR-positive B cell enhancer ABC_E11198 Neighboring gene microRNA 92b Neighboring gene tripartite motif-containing 46 Neighboring gene keratinocyte associated protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E4552 Neighboring gene dolichyl-phosphate mannosyltransferase polypeptide 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in apical plasma membrane  
    located_in apical plasma membrane PubMed 
    located_in apical plasma membrane  
    located_in cell surface PubMed 
    located_in chromatin  
    located_in collagen-containing extracellular matrix PubMed 
    located_in cytoplasm  
    located_in extracellular exosome  
    located_in nucleus  
    located_in plasma membrane  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013605.2NP_038633.1  mucin-1 precursor

      See identical proteins and their annotated locations for NP_038633.1

      Status: VALIDATED

      Source sequence(s)
      AC132327, AW913641, BG079301, CJ066040
      Consensus CDS
      CCDS17496.1
      UniProtKB/TrEMBL
      A0A0R4J0H1, Q99K60
      Related
      ENSMUSP00000041963.4, ENSMUST00000041142.4
      Conserved Domains (1) summary
      smart00200
      Location:412528
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      89136363..89140688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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