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    Xkr6 X-linked Kx blood group related 6 [ Mus musculus (house mouse) ]

    Gene ID: 219149, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Xkr6provided by MGI
    Official Full Name
    X-linked Kx blood group related 6provided by MGI
    Primary source
    MGI:MGI:2447765
    See related
    Ensembl:ENSMUSG00000035067 AllianceGenome:MGI:2447765
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Xrg6; 2700008G24Rik
    Summary
    Predicted to be involved in apoptotic process involved in development; engulfment of apoptotic cell; and phosphatidylserine exposure on apoptotic cell surface. Is active in plasma membrane. Is expressed in nervous system. Orthologous to human XKR6 (XK related 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 2.4), cerebellum adult (RPKM 2.0) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Xkr6 in Genome Data Viewer
    Location:
    14 D1; 14 33.34 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (63841608..64084451)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (63606530..63845706)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36926 Neighboring gene predicted gene 17232 Neighboring gene STARR-positive B cell enhancer ABC_E8564 Neighboring gene L-threonine dehydrogenase Neighboring gene myotubularin related protein 9 Neighboring gene VISTA enhancer mm1542 Neighboring gene predicted gene 15918 Neighboring gene STARR-seq mESC enhancer starr_36930 Neighboring gene STARR-seq mESC enhancer starr_36931 Neighboring gene predicted gene, 38524 Neighboring gene microRNA 598 Neighboring gene predicted gene, 36218 Neighboring gene STARR-seq mESC enhancer starr_36932 Neighboring gene predicted gene, 41175 Neighboring gene PIN2/TERF1 interacting, telomerase inhibitor 1 Neighboring gene SRY (sex determining region Y)-box 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exposure of phosphatidylserine by Xk-related protein family members during apoptosis. Suzuki J, et al. J Biol Chem, 2014 Oct 31. PMID 25231987, Free PMC Article
    2. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC37452

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process involved in development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in engulfment of apoptotic cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylserine exposure on apoptotic cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    XK-related protein 6
    Names
    X Kell blood group precursor related family member 6 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173393.2 → NP_775569.2  XK-related protein 6

      See identical proteins and their annotated locations for NP_775569.2

      Status: VALIDATED

      Source sequence(s)
      AC118607, AC120788, AY534252
      Consensus CDS
      CCDS27204.2
      UniProtKB/Swiss-Prot
      E9Q6C8, G3X9Y8, Q5GH65, Q8R1I8
      Related
      ENSMUSP00000113708.3, ENSMUST00000119973.3
      Conserved Domains (1) summary
      pfam09815
      Location:131 → 497
      XK-related; XK-related protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      63841608..64084451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158567.1 → XP_036014460.1  XK-related protein 6 isoform X1

      Conserved Domains (1) summary
      pfam09815
      Location:127 → 418
      XK-related; XK-related protein

    2. XM_006518881.5 → XP_006518944.1  XK-related protein 6 isoform X4

      See identical proteins and their annotated locations for XP_006518944.1

      UniProtKB/Swiss-Prot
      E9Q6C8
      Related
      ENSMUSP00000112691.3, ENSMUST00000120820.3
      Conserved Domains (1) summary
      pfam09815
      Location:1 → 241
      XK-related; XK-related protein

    3. XM_017315977.3 → XP_017171466.1  XK-related protein 6 isoform X2

      Conserved Domains (1) summary
      pfam09815
      Location:33 → 280
      XK-related; XK-related protein

    4. XM_006518880.5 → XP_006518943.1  XK-related protein 6 isoform X3

      Conserved Domains (1) summary
      pfam09815
      Location:26 → 270
      XK-related; XK-related protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q6C8.1 GenPept UniProtKB/Swiss-Prot:E9Q6C8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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