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    Kcnk13 potassium channel, subfamily K, member 13 [ Mus musculus (house mouse) ]

    Gene ID: 217826, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcnk13provided by MGI
    Official Full Name
    potassium channel, subfamily K, member 13provided by MGI
    Primary source
    MGI:MGI:2384976
    See related
    Ensembl:ENSMUSG00000045404 AllianceGenome:MGI:2384976
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1570; Gm1685; F730021E22Rik
    Summary
    Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in dentate gyrus subgranular zone and heart. Orthologous to human KCNK13 (potassium two pore domain channel subfamily K member 13). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 2.1), frontal lobe adult (RPKM 1.7) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kcnk13 in Genome Data Viewer
    Location:
    12 E; 12 50.43 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (99928132..100028941)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (99963149..100062682)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 11 Neighboring gene STARR-seq mESC enhancer starr_33028 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr12:101121576-101121877 Neighboring gene STARR-seq mESC enhancer starr_33029 Neighboring gene STARR-positive B cell enhancer mm9_chr12:101140770-101141071 Neighboring gene predicted gene, 57807 Neighboring gene tyrosyl-DNA phosphodiesterase 1 Neighboring gene STARR-seq mESC enhancer starr_33030 Neighboring gene predicted gene, 51957 Neighboring gene malate dehydrogenase 1, NAD (soluble) pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr12:101348195-101348496 Neighboring gene protease (prosome, macropain) 26S subunit, ATPase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The two pore potassium channel THIK-1 regulates NLRP3 inflammasome activation. Drinkall S, et al. Glia, 2022 Jul. PMID 35353387, Free PMC Article
    2. Differential contribution of THIK-1 K(+) channels and P2X7 receptors to ATP-mediated neuroinflammation by human microglia. Rifat A, et al. J Neuroinflammation, 2024 Feb 26. PMID 38409076, Free PMC Article
    3. Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome. Ossola B, et al. Neuropharmacology, 2023 Feb 15. PMID 36375694, Free PMC Article
    4. KCNK13 potassium channels in the ventral tegmental area of rats are important for excitation of ventral tegmental area neurons by ethanol. You C, et al. Alcohol Clin Exp Res, 2021 Jul. PMID 33960499, Free PMC Article
    5. Synapse development is regulated by microglial THIK-1 K(+) channels. Izquierdo P, et al. Proc Natl Acad Sci U S A, 2021 Oct 19. PMID 34642249, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The two pore potassium channel THIK-1 regulates NLRP3 inflammasome activation.
      Title: The two pore potassium channel THIK-1 regulates NLRP3 inflammasome activation.
    2. KCNK13 potassium channels in the ventral tegmental area of rats are important for excitation of ventral tegmental area neurons by ethanol.
      Title: KCNK13 potassium channels in the ventral tegmental area of rats are important for excitation of ventral tegmental area neurons by ethanol.
    3. THIK-1 is the main K(+) channel expressed in microglia in situ. THIK-1 is tonically active, and its activity is potentiated by P2Y12 receptors. Microglial immune surveillance and cytokine release require THIK-1 channel activity.
      Title: Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K(+) Channel THIK-1.
    4. Dysregulation of a potassium channel, THIK-1, targeted by caspase-8, accelerates cell shrinkage.
      Title: Dysregulation of a potassium channel, THIK-1, targeted by caspase-8 accelerates cell shrinkage.
    5. THIK-1 and THIK-2 are abundantly expressed in the proximal and distal nephron of the mammalian kidney.
      Title: Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC31053

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of NLRP3 inflammasome complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of excitatory synapse pruning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of resting membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    potassium channel subfamily K member 13
    Names
    THIK-1
    tandem pore domain halothane-inhibited potassium channel 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164426.1 → NP_001157898.1  potassium channel subfamily K member 13

      See identical proteins and their annotated locations for NP_001157898.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC159243
      Consensus CDS
      CCDS26106.1
      UniProtKB/Swiss-Prot
      Q8R1P5
      UniProtKB/TrEMBL
      Q3TYG8
      Related
      ENSMUSP00000136882.2, ENSMUST00000177549.8
      Conserved Domains (1) summary
      pfam07885
      Location:88 → 150
      Ion_trans_2; Ion channel

    2. NM_001164427.1 → NP_001157899.1  potassium channel subfamily K member 13

      See identical proteins and their annotated locations for NP_001157899.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC159243
      Consensus CDS
      CCDS26106.1
      UniProtKB/Swiss-Prot
      Q8R1P5
      UniProtKB/TrEMBL
      Q3TYG8
      Related
      ENSMUSP00000051846.9, ENSMUST00000049788.9
      Conserved Domains (1) summary
      pfam07885
      Location:88 → 150
      Ion_trans_2; Ion channel

    3. NM_146037.2 → NP_666149.1  potassium channel subfamily K member 13

      See identical proteins and their annotated locations for NP_666149.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC159243
      Consensus CDS
      CCDS26106.1
      UniProtKB/Swiss-Prot
      Q8R1P5
      UniProtKB/TrEMBL
      Q3TYG8
      Related
      ENSMUSP00000123916.2, ENSMUST00000160413.8
      Conserved Domains (1) summary
      pfam07885
      Location:88 → 150
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      99928132..100028941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246665.2 → XP_030102525.1  potassium channel subfamily K member 13 isoform X1

      UniProtKB/Swiss-Prot
      Q8R1P5
      UniProtKB/TrEMBL
      Q3TYG8
      Conserved Domains (1) summary
      pfam07885
      Location:88 → 150
      Ion_trans_2; Ion channel

    2. XM_036157341.1 → XP_036013234.1  potassium channel subfamily K member 13 isoform X1

      UniProtKB/Swiss-Prot
      Q8R1P5
      UniProtKB/TrEMBL
      Q3TYG8
      Conserved Domains (1) summary
      pfam07885
      Location:88 → 150
      Ion_trans_2; Ion channel
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R1P5.1 GenPept UniProtKB/Swiss-Prot:Q8R1P5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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