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    Spns3 SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative) [ Mus musculus (house mouse) ]

    Gene ID: 77577, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spns3provided by MGI
    Official Full Name
    SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)provided by MGI
    Primary source
    MGI:MGI:1924827
    See related
    Ensembl:ENSMUSG00000020798 AllianceGenome:MGI:1924827
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9830002I17Rik
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in lipid transport and transmembrane transport. Predicted to be active in membrane. Orthologous to human SPNS3 (SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 8.8), thymus adult (RPKM 4.2) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Spns3 in Genome Data Viewer
    Location:
    11 B4; 11 44.34 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72388979..72441334, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72498153..72550509, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8422 Neighboring gene MYB binding protein (P160) 1a Neighboring gene Spns2 opposite strand Neighboring gene SPNS lysolipid transporter 2, sphingosine-1-phosphate Neighboring gene STARR-seq mESC enhancer starr_29912 Neighboring gene STARR-positive B cell enhancer ABC_E8423 Neighboring gene STARR-seq mESC enhancer starr_29914 Neighboring gene predicted gene, 51906 Neighboring gene predicted gene 12712 Neighboring gene STARR-positive B cell enhancer ABC_E2360 Neighboring gene STARR-positive B cell enhancer ABC_E5245 Neighboring gene ubiquitin-conjugating enzyme E2G 1 Neighboring gene predicted gene, 24143

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. Jacobsson JA, et al. Genomics, 2007 Nov. PMID 17714910
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein spinster homolog 3
    Names
    spinster homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029932.3 → NP_084208.1  protein spinster homolog 3

      See identical proteins and their annotated locations for NP_084208.1

      Status: PROVISIONAL

      Source sequence(s)
      AL662812
      Consensus CDS
      CCDS24987.1
      UniProtKB/Swiss-Prot
      B2RX04, Q3U0X5, Q8BYA9, Q9D232
      Related
      ENSMUSP00000090617.7, ENSMUST00000092940.13
      Conserved Domains (2) summary
      cd06174
      Location:53 → 470
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:55 → 418
      MFS_1; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      72388979..72441334 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534486.1 → XP_006534549.1  protein spinster homolog 3 isoform X1

      Conserved Domains (1) summary
      cd17328
      Location:53 → 447
      MFS_spinster_like; Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters

    2. XM_011249311.1 → XP_011247613.1  protein spinster homolog 3 isoform X2

      See identical proteins and their annotated locations for XP_011247613.1

      Conserved Domains (1) summary
      cd17328
      Location:16 → 257
      MFS_spinster_like; Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters

    3. XM_006534488.5 → XP_006534551.1  protein spinster homolog 3 isoform X2

      See identical proteins and their annotated locations for XP_006534551.1

      Conserved Domains (1) summary
      cd17328
      Location:16 → 257
      MFS_spinster_like; Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters

    RNA

    1. XR_388557.4 RNA Sequence

    2. XR_388556.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D232.1 GenPept UniProtKB/Swiss-Prot:Q9D232

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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