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    P2rx6 purinergic receptor P2X, ligand-gated ion channel, 6 [ Mus musculus (house mouse) ]

    Gene ID: 18440, updated on 27-Dec-2024

    Summary

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    Official Symbol
    P2rx6provided by MGI
    Official Full Name
    purinergic receptor P2X, ligand-gated ion channel, 6provided by MGI
    Primary source
    MGI:MGI:1337113
    See related
    Ensembl:ENSMUSG00000022758 AllianceGenome:MGI:1337113
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P2x6; P2xm; P2rxl1
    Summary
    Predicted to enable extracellularly ATP-gated monoatomic cation channel activity. Predicted to be involved in calcium ion transmembrane transport. Located in neuronal cell body and nucleus. Is expressed in central nervous system; heart; parathyroid gland; reproductive system; and respiratory system. Orthologous to human P2RX6 (purinergic receptor P2X 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 7.9), ovary adult (RPKM 5.8) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See P2rx6 in Genome Data Viewer
    Location:
    16 A3; 16 10.88 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17379749..17389879)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17561867..17572015)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17531169-17531278 Neighboring gene THAP domain containing 7 Neighboring gene leucine rich repeat containing 74B Neighboring gene STARR-positive B cell enhancer ABC_E10890 Neighboring gene STARR-seq mESC enhancer starr_40257 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 4 Neighboring gene STARR-seq mESC enhancer starr_40258 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17619324-17619507 Neighboring gene sphingomyelin phosphodiesterase 4 Neighboring gene STARR-seq mESC enhancer starr_40259

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. P2X6 Knockout Mice Exhibit Normal Electrolyte Homeostasis. de Baaij JH, et al. PLoS One, 2016. PMID 27254077, Free PMC Article
    2. Cloning and characterization of the murine P2XM receptor gene. Nawa G, et al. J Hum Genet, 1998. PMID 9852680
    3. Age-related nuclear translocation of P2X6 subunit modifies splicing activity interacting with splicing factor 3A1. Díaz-Hernández JI, et al. PLoS One, 2015. PMID 25874565, Free PMC Article
    4. Distribution of immunoreactivity for P2X3, P2X5, and P2X6-purinoceptors in mouse retina. Shigematsu Y, et al. J Mol Histol, 2007 Aug. PMID 17605080
    5. P2X receptors are expressed on neurons containing luteinizing hormone-releasing hormone in the mouse hypothalamus. Fu J, et al. Neurosci Lett, 2009 Jul 10. PMID 19442872

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. purinergic signaling via P2X6 is not significantly involved in the regulation of renal electrolyte handling under normal physiological conditions.
      Title: P2X6 Knockout Mice Exhibit Normal Electrolyte Homeostasis.
    2. once inside the nucleus, P2X6 subunit interacts with the splicing factor 3A1, which ultimately results in a reduction of the mRNA splicing activity
      Title: Age-related nuclear translocation of P2X6 subunit modifies splicing activity interacting with splicing factor 3A1.
    3. This study provides the first evidence that P2X8 receptors are expressed on LHRH-containing neurons.
      Title: P2X receptors are expressed on neurons containing luteinizing hormone-releasing hormone in the mouse hypothalamus.
    4. Immunoreactivity for P2X3-, P2X5-, and P2X6-purinoceptors was observed in mouse retina.
      Title: Distribution of immunoreactivity for P2X3, P2X5, and P2X6-purinoceptors in mouse retina.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC141601

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables extracellularly ATP-gated monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellularly ATP-gated monoatomic cation channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables extracellularly ATP-gated monoatomic cation channel activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables purinergic nucleotide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to ATP IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in parallel fiber to Purkinje cell synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in parallel fiber to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in postsynaptic specialization membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    P2X purinoceptor 6
    Names
    ATP receptor
    purinergic receptor P2X-like 1, orphan receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159561.1 → NP_001153033.1  P2X purinoceptor 6 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AK138541, AW490413, BC117713, BY303078
      Consensus CDS
      CCDS49778.1
      UniProtKB/TrEMBL
      E9PY29, Q149L9
      Related
      ENSMUSP00000132727.2, ENSMUST00000171002.10
      Conserved Domains (1) summary
      TIGR00863
      Location:19 → 349
      P2X; cation transporter protein

    2. NM_011028.2 → NP_035158.2  P2X purinoceptor 6 isoform 1

      See identical proteins and their annotated locations for NP_035158.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK138541, AW490413, BY303078
      Consensus CDS
      CCDS28007.2
      UniProtKB/Swiss-Prot
      G3X8W3, O54803, Q3UUD0
      UniProtKB/TrEMBL
      Q149L9
      Related
      ENSMUSP00000023441.5, ENSMUST00000023441.11
      Conserved Domains (1) summary
      TIGR00863
      Location:19 → 376
      P2X; cation transporter protein

    RNA

    1. NR_189665.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC115733

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      17379749..17389879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54803.3 GenPept UniProtKB/Swiss-Prot:O54803

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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