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    Zbtb25 zinc finger and BTB domain containing 25 [ Mus musculus (house mouse) ]

    Gene ID: 109929, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zbtb25provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 25provided by MGI
    Primary source
    MGI:MGI:99197
    See related
    Ensembl:ENSMUSG00000056459 AllianceGenome:MGI:99197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kup; Zfp50; Zfp-50; 2810462M08Rik; 2900064P18Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Is expressed in genitourinary system. Orthologous to human ZBTB25 (zinc finger and BTB domain containing 25). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 3.3), limb E14.5 (RPKM 3.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zbtb25 in Genome Data Viewer
    Location:
    12 C3; 12 33.73 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (76387168..76416988, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (76348900..76370214, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase Neighboring gene predicted gene, 40443 Neighboring gene A kinase anchor protein 5 Neighboring gene STARR-seq mESC enhancer starr_32516 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:77468237-77468545 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:77468685-77468794 Neighboring gene RIKEN cDNA 4930426I24 gene Neighboring gene zinc finger and BTB domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E94 Neighboring gene STARR-seq mESC enhancer starr_32522 Neighboring gene heat shock protein 2 Neighboring gene protein phosphatase 1, regulatory subunit 36 Neighboring gene predicted gene, 25563

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The KUP gene, located on human chromosome 14, encodes a protein with two distant zinc fingers. Chardin P, et al. Nucleic Acids Res, 1991 Apr 11. PMID 2027750, Free PMC Article
    2. Refinement of the DNA marker maps of mouse chromosome 12. Khan F, et al. Genomics, 1994 May 1. PMID 8088780
    3. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 25
    Names
    zinc finger protein 50

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172104.1 → NP_001165575.1  zinc finger and BTB domain-containing protein 25

      See identical proteins and their annotated locations for NP_001165575.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124453
      Consensus CDS
      CCDS25991.2
      UniProtKB/TrEMBL
      G3UW50
      Related
      ENSMUSP00000128471.2, ENSMUST00000167011.8
      Conserved Domains (3) summary
      sd00018
      Location:239 → 261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:241 → 261
      zf-C2H2; Zinc finger, C2H2 type
      cd18213
      Location:3 → 130
      BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)

    2. NM_028356.2 → NP_082632.2  zinc finger and BTB domain-containing protein 25

      See identical proteins and their annotated locations for NP_082632.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124453
      Consensus CDS
      CCDS25991.2
      UniProtKB/TrEMBL
      G3UW50
      Related
      ENSMUSP00000134748.2, ENSMUST00000176278.8
      Conserved Domains (3) summary
      sd00018
      Location:239 → 261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:241 → 261
      zf-C2H2; Zinc finger, C2H2 type
      cd18213
      Location:3 → 130
      BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      76387168..76416988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314936.3 → XP_017170425.2  zinc finger and BTB domain-containing protein 25 isoform X3

      UniProtKB/TrEMBL
      Q6NV93
      Conserved Domains (2) summary
      sd00018
      Location:126 → 148
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:128 → 148
      zf-C2H2; Zinc finger, C2H2 type

    2. XM_006515397.3 → XP_006515460.1  zinc finger and BTB domain-containing protein 25 isoform X2

      See identical proteins and their annotated locations for XP_006515460.1

      UniProtKB/TrEMBL
      G3UW50
      Conserved Domains (3) summary
      sd00018
      Location:239 → 261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:241 → 261
      zf-C2H2; Zinc finger, C2H2 type
      cd18213
      Location:3 → 130
      BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)

    3. XM_030246520.2 → XP_030102380.1  zinc finger and BTB domain-containing protein 25 isoform X3

      UniProtKB/TrEMBL
      Q6NV93
      Conserved Domains (2) summary
      sd00018
      Location:126 → 148
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:128 → 148
      zf-C2H2; Zinc finger, C2H2 type

    4. XM_030246517.2 → XP_030102377.1  zinc finger and BTB domain-containing protein 25 isoform X2

      UniProtKB/TrEMBL
      G3UW50
      Conserved Domains (3) summary
      sd00018
      Location:239 → 261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:241 → 261
      zf-C2H2; Zinc finger, C2H2 type
      cd18213
      Location:3 → 130
      BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)

    5. XM_030246519.2 → XP_030102379.1  zinc finger and BTB domain-containing protein 25 isoform X3

      UniProtKB/TrEMBL
      Q6NV93
      Conserved Domains (2) summary
      sd00018
      Location:126 → 148
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:128 → 148
      zf-C2H2; Zinc finger, C2H2 type

    6. XM_006515396.3 → XP_006515459.1  zinc finger and BTB domain-containing protein 25 isoform X2

      See identical proteins and their annotated locations for XP_006515459.1

      UniProtKB/TrEMBL
      G3UW50
      Conserved Domains (3) summary
      sd00018
      Location:239 → 261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:241 → 261
      zf-C2H2; Zinc finger, C2H2 type
      cd18213
      Location:3 → 130
      BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)

    7. XM_030246518.2 → XP_030102378.1  zinc finger and BTB domain-containing protein 25 isoform X3

      UniProtKB/TrEMBL
      Q6NV93
      Conserved Domains (2) summary
      sd00018
      Location:126 → 148
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:128 → 148
      zf-C2H2; Zinc finger, C2H2 type

    8. XM_006515400.3 → XP_006515463.1  zinc finger and BTB domain-containing protein 25 isoform X3

      See identical proteins and their annotated locations for XP_006515463.1

      UniProtKB/TrEMBL
      Q6NV93
      Conserved Domains (2) summary
      sd00018
      Location:126 → 148
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:128 → 148
      zf-C2H2; Zinc finger, C2H2 type

    9. XM_006515394.3 → XP_006515457.1  zinc finger and BTB domain-containing protein 25 isoform X2

      See identical proteins and their annotated locations for XP_006515457.1

      UniProtKB/TrEMBL
      G3UW50
      Conserved Domains (3) summary
      sd00018
      Location:239 → 261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:241 → 261
      zf-C2H2; Zinc finger, C2H2 type
      cd18213
      Location:3 → 130
      BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)

    10. XM_006515393.3 → XP_006515456.1  zinc finger and BTB domain-containing protein 25 isoform X2

      See identical proteins and their annotated locations for XP_006515456.1

      UniProtKB/TrEMBL
      G3UW50
      Conserved Domains (3) summary
      sd00018
      Location:239 → 261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:241 → 261
      zf-C2H2; Zinc finger, C2H2 type
      cd18213
      Location:3 → 130
      BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)

    11. XM_030246516.2 → XP_030102376.1  zinc finger and BTB domain-containing protein 25 isoform X2

      UniProtKB/TrEMBL
      G3UW50
      Conserved Domains (3) summary
      sd00018
      Location:239 → 261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:241 → 261
      zf-C2H2; Zinc finger, C2H2 type
      cd18213
      Location:3 → 130
      BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)

    12. XM_006515399.3 → XP_006515462.1  zinc finger and BTB domain-containing protein 25 isoform X2

      See identical proteins and their annotated locations for XP_006515462.1

      UniProtKB/TrEMBL
      G3UW50
      Conserved Domains (3) summary
      sd00018
      Location:239 → 261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:241 → 261
      zf-C2H2; Zinc finger, C2H2 type
      cd18213
      Location:3 → 130
      BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)

    13. XM_006515392.5 → XP_006515455.1  zinc finger and BTB domain-containing protein 25 isoform X1

      Conserved Domains (5) summary
      smart00355
      Location:548 → 568
      ZnF_C2H2; zinc finger
      PHA03307
      Location:2 → 250
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00018
      Location:432 → 454
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:434 → 454
      zf-C2H2; Zinc finger, C2H2 type
      cl38908
      Location:249 → 323
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    Nucleotide Protein Strain
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