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    TAS2R45 taste 2 receptor member 45 [ Homo sapiens (human) ]

    Gene ID: 259291, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TAS2R45provided by HGNC
    Official Full Name
    taste 2 receptor member 45provided by HGNC
    Primary source
    HGNC:HGNC:18876
    See related
    MIM:613967; AllianceGenome:HGNC:18876
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPR59; T2R45; ZG24P
    Summary
    Predicted to enable G protein-coupled receptor activity and bitter taste receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of bitter taste. Located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: only annotated on alternate loci in reference assembly
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    Genomic context

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    See TAS2R45 in Genome Data Viewer
    Location:
    12p13.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 (ALT_REF_LOCI_2) NT_187658.1 (291887..292786, complement)
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 (ALT_REF_LOCI_1) NW_003571050.1 (327525..328424, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10966219..10967118, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 (PATCHES) NW_003571050.1 (327525..328424, complement)

    NW_003571050.1Genomic Context describing neighboring genes Neighboring gene PRH1-PRR4 readthrough Neighboring gene proline rich protein HaeIII subfamily 1 Neighboring gene PRH1-TAS2R14 readthrough Neighboring gene taste 2 receptor member 43 Neighboring gene taste 2 receptor member 68 pseudogene Neighboring gene taste 2 receptor member 30 Neighboring gene taste 2 receptor member 18 pseudogene

    NT_187658.1Genomic Context describing neighboring genes Neighboring gene PRH1-PRR4 readthrough Neighboring gene proline rich protein HaeIII subfamily 1 Neighboring gene PRH1-TAS2R14 readthrough Neighboring gene taste 2 receptor member 46 Neighboring gene taste 2 receptor member 68 pseudogene Neighboring gene taste 2 receptor member 30 Neighboring gene small integral membrane protein 10 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Bufe B, et al. Nat Genet, 2002 Nov. PMID 12379855
    2. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. Go Y, et al. Genetics, 2005 May. PMID 15744053, Free PMC Article
    3. The molecular receptive ranges of human TAS2R bitter taste receptors. Meyerhof W, et al. Chem Senses, 2010 Feb. PMID 20022913
    4. Receptors for bitter and sweet taste. Montmayeur JP, et al. Curr Opin Neurobiol, 2002 Aug. PMID 12139982
    5. Molecular mechanisms of bitter and sweet taste transduction. Margolskee RF. J Biol Chem, 2002 Jan 4. PMID 11696554

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC119923, MGC119924, MGC119925

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables bitter taste receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in detection of chemical stimulus involved in sensory perception of bitter taste IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    taste receptor type 2 member 45
    Names
    G-protein coupled receptor 59
    taste receptor, type 2, member 45

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176886.2 → NP_795367.2  taste receptor type 2 member 45

      See identical proteins and their annotated locations for NP_795367.2

      Status: VALIDATED

      Source sequence(s)
      AC217021
      UniProtKB/Swiss-Prot
      P59539
      UniProtKB/TrEMBL
      A0A0J9YXD8
      Conserved Domains (1) summary
      pfam05296
      Location:1 → 298
      TAS2R; Taste receptor protein (TAS2R)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003571050.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      327525..328424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187658.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      291887..292786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      10966219..10967118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59539.1 GenPept UniProtKB/Swiss-Prot:P59539

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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