Zwint ZW10 interacting kinetochore protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zwintprovided by RGD
Official Full Name: ZW10 interacting kinetochore proteinprovided by RGD
Primary source: RGD:628671
See related: EnsemblRapid:ENSRNOG00000048682 AllianceGenome:RGD:628671
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sip30; Zwint-1
Summary: Predicted to be involved in nuclear chromosome segregation and regulation of metaphase/anaphase transition of cell cycle. Located in dendrite. Orthologous to human ZWINT (ZW10 interacting kinetochore protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 4963.2), Adrenal (RPKM 532.6) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (15502559..15953701, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (15938157..15953997, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (17075781..17091715, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

our results highlight SIP30 as a target to mediate neuropathic pain-evoked negative emotion
Title: SIP30 is required for neuropathic pain-evoked aversion in rats.
there is an ERK-responsive region in the rat sip30 promoter. Activation of ERK promotes the recruitment of the transcription factor cyclic AMP-response element-binding protein to the sip30 gene promoter
Title: SIP30 is regulated by ERK in peripheral nerve injury-induced neuropathic pain.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129520 (e-PCR)
- UniSTS:212823

RH127633 (e-PCR)
- UniSTS:210943

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in establishment of localization in cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in homologous chromosome orientation in meiotic metaphase I	ISO Inferred from Sequence Orthology more info
involved_in homologous chromosome orientation in meiotic metaphase I	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic sister chromatid segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic sister chromatid segregation	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of meiosis I spindle assembly checkpoint	ISO Inferred from Sequence Orthology more info
involved_in regulation of meiosis I spindle assembly checkpoint	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Knl1/Spc105 complex	ISO Inferred from Sequence Orthology more info
part_of Knl1/Spc105 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nuclear body	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of outer kinetochore	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: outer kinetochore KNL1 complex subunit ZWINT; ZW10 interactor

Names: SNAP25-interacting protein 30; ZW10 interacting protein-1; ZW10 interactor, kinetochore protein; neuroprotective protein 8; scoilin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_147138.3 → NP_671479.1 outer kinetochore KNL1 complex subunit ZWINT

See identical proteins and their annotated locations for NP_671479.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

Q546Y5, Q8VIL3

UniProtKB/TrEMBL

A0A8I6A1E2, A6JKM9

Related

ENSRNOP00000067414.1, ENSRNOT00000074404.4

Conserved Domains (1) summary

pfam15556
Location:51 → 252

Zwint; ZW10 interactor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

15502559..15953701 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063278987.1 → XP_063135057.1 ZW10 interactor isoform X1

UniProtKB/Swiss-Prot

Q546Y5, Q8VIL3

UniProtKB/TrEMBL

A0A8I6A1E2, A6JKM9
XM_039098465.2 → XP_038954393.1 ZW10 interactor isoform X1

UniProtKB/Swiss-Prot

Q546Y5, Q8VIL3

UniProtKB/TrEMBL

A0A8I6A1E2, A6JKM9

Conserved Domains (1) summary

pfam15556
Location:51 → 252

Zwint; ZW10 interactor