Il1rl1 interleukin 1 receptor-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il1rl1provided by RGD
Official Full Name: interleukin 1 receptor-like 1provided by RGD
Primary source: RGD:2894
See related: EnsemblRapid:ENSRNOG00000014835 AllianceGenome:RGD:2894
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: St2; FIT1; Fit-1
Summary: Predicted to enable interleukin-33 binding activity and interleukin-33 receptor activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to peptide; and negative regulation of cell population proliferation. Located in external side of plasma membrane and extracellular space. Biomarker of acute myocardial infarction and bacterial pneumonia. Human ortholog(s) of this gene implicated in asthma and coronary artery disease. Orthologous to human IL1RL1 (interleukin 1 receptor like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 50.7), Lung (RPKM 21.2) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q22

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (50157326..50222888)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (42661694..42727266)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (47133483..47184316)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanistic role of RND3-regulated IL33/ST2 signaling on cardiomyocyte senescence.
Title: Mechanistic role of RND3-regulated IL33/ST2 signaling on cardiomyocyte senescence.
Electroacupuncture prevents the development or establishment of chronic pain via IL-33/ST2 signaling in hyperalgesic priming model rats.
Title: Electroacupuncture prevents the development or establishment of chronic pain via IL-33/ST2 signaling in hyperalgesic priming model rats.
Unveiling IL-33/ST2 Pathway Unbalance in Cardiac Remodeling Due to Obesity in Zucker Fatty Rats.
Title: Unveiling IL-33/ST2 Pathway Unbalance in Cardiac Remodeling Due to Obesity in Zucker Fatty Rats.
ST2 silencing aggravates ventricular remodeling and chronic heart failure in rats by mediating the IL-33/ST2 axis.
Title: ST2 silencing aggravates ventricular remodeling and chronic heart failure in rats by mediating the IL-33/ST2 axis.
MicroRNA-547-5p-mediated interleukin-33/suppressor of tumorigenicity 2 signaling underlies the genesis and maintenance of neuropathic pain and is targeted by the therapy with bone marrow stromal cells.
Title: MicroRNA-547-5p-mediated interleukin-33/suppressor of tumorigenicity 2 signaling underlies the genesis and maintenance of neuropathic pain and is targeted by the therapy with bone marrow stromal cells.
he transcription factor Yy1 regulates sST2 expression, and repression of Yy1 by metformin results in lower levels of sST2 that are associated with favorable myocardial remodeling. The manipulation of YY1 or its co-repressor HDAC4 emerge as new targets to modulate ST2/IL33 signaling and prevent adverse cardiac remodeling.
Title: Yin-Yang 1 transcription factor modulates ST2 expression during adverse cardiac remodeling post-myocardial infarction.
Calycosin treatment markedly improved the aforementioned makers of renal injury and dysfunction, modulated IL33/ST2 signaling.
Title: Renoprotective effect of calycosin in high fat diet-fed/STZ injected rats: Effect on IL-33/ST2 signaling, oxidative stress and fibrosis suppression.
The lungs are a relevant source of sST2 in heart failure, shich may have implications for disease progression.
Title: Pulmonary Production of Soluble ST2 in Heart Failure.
ST2/IL-33 signaling plays an important role in the development of radicular pain in lumbar disk herniation.
Title: IL-33/ST2 signaling contributes to radicular pain by modulating MAPK and NF-κB activation and inflammatory mediator expression in the spinal cord in rat models of noncompressive lumber disk herniation.
administration of sST2 significantly attenuated the severity of severe acute pancreatitis and associated cardiac damage, and the cardioprotective effect is associated with its anti-inflammatory action
Title: Adenovirus-mediated overexpression of sST2 attenuates cardiac injury in the rat with severe acute pancreatitis.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD+ nucleosidase activity	IEA Inferred from Electronic Annotation more info
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables interleukin-1 receptor activity	IEA Inferred from Electronic Annotation more info
enables interleukin-33 binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-33 binding	IEA Inferred from Electronic Annotation more info
enables interleukin-33 binding	ISO Inferred from Sequence Orthology more info
enables interleukin-33 receptor activity	IEA Inferred from Electronic Annotation more info
enables interleukin-33 receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to peptide	IEP Inferred from Expression Pattern more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in interleukin-33-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-33-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-33-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in macrophage differentiation	IEA Inferred from Electronic Annotation more info
involved_in macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in macrophage differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T-helper 1 type immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T-helper 1 type immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-5 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-5 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-1 receptor-like 1

Names: fos-responsive gene 1 protein

NP_001121161.1

EC 3.2.2.6

NP_037169.1

EC 3.2.2.6

XP_006244801.1

EC 3.2.2.6

XP_006244802.1

EC 3.2.2.6

XP_008765214.1

EC 3.2.2.6

XP_017451779.1

EC 3.2.2.6

XP_038938998.1

EC 3.2.2.6

XP_038938999.1

EC 3.2.2.6

XP_038939000.1

EC 3.2.2.6

XP_038939001.1

EC 3.2.2.6

XP_063122776.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127689.1 → NP_001121161.1 interleukin-1 receptor-like 1 isoform Fit-1M precursor

See identical proteins and their annotated locations for NP_001121161.1

Status: PROVISIONAL

Source sequence(s)

U04317

UniProtKB/Swiss-Prot

Q62611, Q62612

UniProtKB/TrEMBL

F1LR63

Conserved Domains (4) summary

cd05757
Location:123 → 210

Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

smart00410
Location:31 → 110

IG_like; Immunoglobulin like

pfam01582
Location:384 → 539

TIR; TIR domain

cl11960
Location:28 → 110

Ig; Immunoglobulin domain
NM_013037.1 → NP_037169.1 interleukin-1 receptor-like 1 isoform Fit-1S precursor

See identical proteins and their annotated locations for NP_037169.1

Status: PROVISIONAL

Source sequence(s)

U04319

UniProtKB/Swiss-Prot

Q62611

Related

ENSRNOP00000103721.1, ENSRNOT00000136818.1

Conserved Domains (3) summary

cd05757
Location:123 → 210

Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

smart00410
Location:31 → 110

IG_like; Immunoglobulin like

cl11960
Location:28 → 110

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

50157326..50222888

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039083070.2 → XP_038938998.1 interleukin-1 receptor-like 1 isoform X1

UniProtKB/TrEMBL

F1LR63

Conserved Domains (4) summary

pfam01582
Location:384 → 539

TIR; TIR domain

cd00096
Location:37 → 42

Ig; Ig strand B [structural motif]

cd05757
Location:123 → 210

Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:33 → 110

Ig; Immunoglobulin domain
XM_039083072.2 → XP_038939000.1 interleukin-1 receptor-like 1 isoform X1

UniProtKB/TrEMBL

F1LR63

Related

ENSRNOP00000020108.5, ENSRNOT00000020108.7

Conserved Domains (4) summary

pfam01582
Location:384 → 539

TIR; TIR domain

cd00096
Location:37 → 42

Ig; Ig strand B [structural motif]

cd05757
Location:123 → 210

Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:33 → 110

Ig; Immunoglobulin domain
XM_008766992.4 → XP_008765214.1 interleukin-1 receptor-like 1 isoform X1

See identical proteins and their annotated locations for XP_008765214.1

UniProtKB/TrEMBL

F1LR63

Conserved Domains (4) summary

pfam01582
Location:384 → 539

TIR; TIR domain

cd00096
Location:37 → 42

Ig; Ig strand B [structural motif]

cd05757
Location:123 → 210

Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:33 → 110

Ig; Immunoglobulin domain
XM_006244740.5 → XP_006244802.1 interleukin-1 receptor-like 1 isoform X1

See identical proteins and their annotated locations for XP_006244802.1

UniProtKB/TrEMBL

F1LR63

Conserved Domains (4) summary

pfam01582
Location:384 → 539

TIR; TIR domain

cd00096
Location:37 → 42

Ig; Ig strand B [structural motif]

cd05757
Location:123 → 210

Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:33 → 110

Ig; Immunoglobulin domain
XM_063266706.1 → XP_063122776.1 interleukin-1 receptor-like 1 isoform X1
XM_006244739.5 → XP_006244801.1 interleukin-1 receptor-like 1 isoform X1

See identical proteins and their annotated locations for XP_006244801.1

UniProtKB/TrEMBL

F1LR63

Conserved Domains (4) summary

pfam01582
Location:384 → 539

TIR; TIR domain

cd00096
Location:37 → 42

Ig; Ig strand B [structural motif]

cd05757
Location:123 → 210

Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:33 → 110

Ig; Immunoglobulin domain
XM_039083071.2 → XP_038938999.1 interleukin-1 receptor-like 1 isoform X1

UniProtKB/TrEMBL

F1LR63

Conserved Domains (4) summary

pfam01582
Location:384 → 539

TIR; TIR domain

cd00096
Location:37 → 42

Ig; Ig strand B [structural motif]

cd05757
Location:123 → 210

Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:33 → 110

Ig; Immunoglobulin domain
XM_017596290.3 → XP_017451779.1 interleukin-1 receptor-like 1 isoform X1

UniProtKB/TrEMBL

F1LR63

Conserved Domains (4) summary

pfam01582
Location:384 → 539

TIR; TIR domain

cd00096
Location:37 → 42

Ig; Ig strand B [structural motif]

cd05757
Location:123 → 210

Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:33 → 110

Ig; Immunoglobulin domain
XM_039083073.2 → XP_038939001.1 interleukin-1 receptor-like 1 isoform X1

UniProtKB/TrEMBL

F1LR63

Conserved Domains (4) summary

pfam01582
Location:384 → 539

TIR; TIR domain

cd00096
Location:37 → 42

Ig; Ig strand B [structural motif]

cd05757
Location:123 → 210

Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:33 → 110

Ig; Immunoglobulin domain