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    Nuak1 NUAK family kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299694, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nuak1provided by RGD
    Official Full Name
    NUAK family kinase 1provided by RGD
    Primary source
    RGD:1309956
    See related
    EnsemblRapid:ENSRNOG00000008061 AllianceGenome:RGD:1309956
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309956
    Summary
    Predicted to enable p53 binding activity and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation; regulation of cell adhesion; and regulation of cellular senescence. Predicted to be located in cytoplasm; microtubule cytoskeleton; and nuclear lumen. Human ortholog(s) of this gene implicated in uterine fibroid. Orthologous to human NUAK1 (NUAK family kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 126.0), Heart (RPKM 112.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nuak1 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (21217729..21289608)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (19330034..19401918)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (25039336..25111118)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479649 Neighboring gene uncharacterized LOC120093542 Neighboring gene uncharacterized LOC134479588 Neighboring gene uncharacterized LOC100910949 Neighboring gene uncharacterized LOC120093543

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Effect of Gender on the Pharmacokinetics of ON 123300, A Dual Inhibitor of ARK5 and CDK4/6 for the Treatment of Cancer, in Rats. Mudunuru J, et al. Eur J Drug Metab Pharmacokinet, 2019 Aug. PMID 30701428
    2. A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation. Hou X, et al. Oncogene, 2011 Jun 30. PMID 21317932
    3. Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. Al-Hakim AK, et al. Biochem J, 2008 Apr 15. PMID 18254724
    4. Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. Humbert N, et al. EMBO J, 2010 Jan 20. PMID 19927127, Free PMC Article
    5. New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. Zagórska A, et al. Sci Signal, 2010 Mar 30. PMID 20354225

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A small molecule dual inhibitor of the c-MYC activated kinases ARK5 and CDK4/6, is being developed.
      Title: Effect of Gender on the Pharmacokinetics of ON 123300, A Dual Inhibitor of ARK5 and CDK4/6 for the Treatment of Cancer, in Rats.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NUAK family SNF1-like kinase 1
    Names
    AMPK-related protein kinase 5
    NUAK family, SNF1-like kinase, 1
    NP_001100244.1
    XP_038934607.1
    XP_038934608.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106774.1 → NP_001100244.1  NUAK family SNF1-like kinase 1

      See identical proteins and their annotated locations for NP_001100244.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473960
      UniProtKB/TrEMBL
      A6IFF8, D3ZQN8
      Related
      ENSRNOP00000010636.5, ENSRNOT00000010636.8
      Conserved Domains (2) summary
      smart00220
      Location:56 → 307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14073
      Location:54 → 307
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      21217729..21289608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078679.2 → XP_038934607.1  NUAK family SNF1-like kinase 1 isoform X1

      Related
      ENSRNOP00000102810.1, ENSRNOT00000150342.1
      Conserved Domains (1) summary
      cl21453
      Location:1 → 175
      PKc_like; Protein Kinases, catalytic domain

    2. XM_039078680.2 → XP_038934608.1  NUAK family SNF1-like kinase 1 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:1 → 21
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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