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    Lingo3 leucine rich repeat and Ig domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690755, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Lingo3provided by RGD
    Official Full Name
    leucine rich repeat and Ig domain containing 3provided by RGD
    Primary source
    RGD:1592209
    See related
    EnsemblRapid:ENSRNOG00000032569 AllianceGenome:RGD:1592209
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human LINGO3 (leucine rich repeat and Ig domain containing 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Brain (RPKM 38.6), Testes (RPKM 6.5) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lingo3 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9519252..9530675)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8869025..8878431)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11737293..11746703)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene signal peptide peptidase-like 2B Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene ornithine decarboxylase antizyme 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene junctional sarcoplasmic reticulum protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109609.1 → NP_001103079.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 precursor

      See identical proteins and their annotated locations for NP_001103079.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474029
      UniProtKB/TrEMBL
      A6K8F1, D3ZW19
      Related
      ENSRNOP00000110002.1, ENSRNOT00000159580.1
      Conserved Domains (7) summary
      TIGR00864
      Location:331 → 405
      PCC; polycystin cation channel protein
      smart00013
      Location:23 → 55
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:55 → 353
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:34 → 53
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:246 → 302
      LRR_8; Leucine rich repeat
      cd00096
      Location:413 → 417
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:407 → 489
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      9519252..9530675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264283.1 → XP_063120353.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 isoform X1

      Related
      ENSRNOP00000051446.4, ENSRNOT00000046059.5
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Other Literature Sources
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