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    Fkbp7 FKBP prolyl isomerase 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295672, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Fkbp7provided by RGD
    Official Full Name
    FKBP prolyl isomerase 7provided by RGD
    Primary source
    RGD:1305293
    See related
    EnsemblRapid:ENSRNOG00000011758 AllianceGenome:RGD:1305293
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in endoplasmic reticulum. Orthologous to human FKBP7 (FKBP prolyl isomerase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 117.5), Uterus (RPKM 99.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fkbp7 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (82016647..82030913, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (61609384..61623710, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (63522480..63535835, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486118 Neighboring gene protein activator of interferon induced protein kinase EIF2AK2 Neighboring gene pejvakin Neighboring gene uncharacterized LOC134486119 Neighboring gene pleckstrin homology domain containing A3 Neighboring gene titin Neighboring gene uncharacterized LOC120101583

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2+-binding ability. Nakamura T, et al. Genomics, 1998 Nov 15. PMID 9806833

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP7
    Names
    FK506 binding protein 7
    NP_001099955.2
    XP_006234462.1
    XP_017447036.1
    XP_038960423.1
    XP_063139346.1
    XP_063139347.1
    XP_063139348.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106485.4 → NP_001099955.2  peptidyl-prolyl cis-trans isomerase FKBP7 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HMI1
      Related
      ENSRNOP00000086609.2, ENSRNOT00000108707.2
      Conserved Domains (3) summary
      cd15899
      Location:147 → 174
      EFh_CREC; EF-hand motif [structural motif]
      cl25354
      Location:147 → 213
      EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family
      pfam00254
      Location:42 → 137
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      82016647..82030913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234400.5 → XP_006234462.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AE14, A6HMI1
      Conserved Domains (3) summary
      pfam00254
      Location:42 → 136
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13499
      Location:147 → 209
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:147 → 208
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. XM_017591547.3 → XP_017447036.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X2

      UniProtKB/TrEMBL
      A6HMI1
      Conserved Domains (3) summary
      cd15899
      Location:147 → 174
      EFh_CREC; EF-hand motif [structural motif]
      cl25354
      Location:147 → 213
      EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family
      pfam00254
      Location:42 → 137
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    3. XM_039104495.2 → XP_038960423.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X6

      Conserved Domains (3) summary
      cd15899
      Location:36 → 65
      EFh_CREC; EF-hand motif [structural motif]
      cl25354
      Location:36 → 107
      EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family
      cl19519
      Location:9 → 28
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    4. XM_063283278.1 → XP_063139348.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X5

    5. XM_063283277.1 → XP_063139347.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A5N3

    6. XM_063283276.1 → XP_063139346.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X1

    RNA

    1. XR_010064576.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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