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    Upp2 uridine phosphorylase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295620, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Upp2provided by RGD
    Official Full Name
    uridine phosphorylase 2provided by RGD
    Primary source
    RGD:1308188
    See related
    EnsemblRapid:ENSRNOG00000005341 AllianceGenome:RGD:1308188
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable deoxyuridine phosphorylase activity; identical protein binding activity; and uridine phosphorylase activity. Predicted to be involved in pyrimidine nucleoside monophosphate catabolic process and uridine catabolic process. Predicted to be located in type III intermediate filament. Predicted to be active in cytosol. Orthologous to human UPP2 (uridine phosphorylase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 64.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Upp2 in Genome Data Viewer
    Location:
    3q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (63681671..63726194)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (43273048..43317417)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (44806106..44846464)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, pseudogene 1 Neighboring gene uncharacterized LOC102556145 Neighboring gene coiled-coil domain containing 148 Neighboring gene basic proline-rich protein-like Neighboring gene plakophilin 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors. Zhang Y, et al. Mol Endocrinol, 2004 Apr. PMID 14715930
    2. Identification of a novel human uridine phosphorylase. Johansson M. Biochem Biophys Res Commun, 2003 Jul 18. PMID 12849978
    3. Uridine phosphorylase association with vimentin. Intracellular distribution and localization. Russell RL, et al. J Biol Chem, 2001 Apr 20. PMID 11278417
    4. Cloning and expression of human uridine phosphorylase. Watanabe S, et al. Biochem Biophys Res Commun, 1995 Nov 2. PMID 7488099
    5. A novel structural mechanism for redox regulation of uridine phosphorylase 2 activity. Roosild TP, et al. J Struct Biol, 2011 Nov. PMID 21855639, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables deoxyuridine phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables uridine phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uridine phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dCMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in uridine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in uridine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in type III intermediate filament ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    uridine phosphorylase 2
    NP_001099951.1
    XP_038960406.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106481.3 → NP_001099951.1  uridine phosphorylase 2

      See identical proteins and their annotated locations for NP_001099951.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JF60, D4A9N9
      Related
      ENSRNOP00000038248.3, ENSRNOT00000035158.5
      Conserved Domains (1) summary
      cl00303
      Location:29 → 310
      PNP_UDP_1; Phosphorylase superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      63681671..63726194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104478.2 → XP_038960406.1  uridine phosphorylase 2 isoform X1

      Conserved Domains (1) summary
      cd17763
      Location:1 → 239
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2
    Nucleotide Protein Strain
    Heading Accession and Version

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