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    Rpp21 ribonuclease P/MRP subunit p21 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 406230, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Rpp21provided by RGD
    Official Full Name
    ribonuclease P/MRP subunit p21provided by RGD
    Primary source
    RGD:1303090
    See related
    EnsemblRapid:ENSRNOG00000000785 EnsemblRapid:ENSRNOG00000000786 AllianceGenome:RGD:1303090
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Flj22638
    Summary
    Predicted to enable ribonuclease P RNA binding activity. Predicted to contribute to ribonuclease P activity. Predicted to be involved in response to xenobiotic stimulus and tRNA 5'-leader removal. Predicted to be part of multimeric ribonuclease P complex. Orthologous to human RPP21 (ribonuclease P/MRP subunit p21). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 397.7), Thymus (RPKM 196.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rpp21 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (1986225..2025308)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (2018170..2020100)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (2515541..2517471)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483841 Neighboring gene peptidylprolyl isomerase D, pseudogene 1 Neighboring gene RT1 class I, locus M10, gene 2, pseudogene Neighboring gene histocompatibility 2, M region locus 10.6 like Neighboring gene RT1 class I, locus M10, gene 1 Neighboring gene RT1 class pseudogene 3082ex4-5 Neighboring gene tripartite motif-containing 39 Neighboring gene RT1 class I, locus P2, pseudogene 1 Neighboring gene Riken clone 5830469G19 related pseudogene 40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Unexpected diversity of RNase P, an ancient tRNA processing enzyme: challenges and prospects. Lai LB, et al. FEBS Lett, 2010 Jan 21. PMID 19931535, Free PMC Article
    2. Sulindac suppresses beta-catenin expression in human cancer cells. Han A, et al. Eur J Pharmacol, 2008 Mar 31. PMID 18291362, Free PMC Article
    3. Differential association of protein subunits with the human RNase MRP and RNase P complexes. Welting TJ, et al. RNA, 2006 Jul. PMID 16723659, Free PMC Article
    4. Cryo-EM Structure of the Human Ribonuclease P Holoenzyme. Wu J, et al. Cell, 2018 Nov 15. PMID 30454648
    5. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, et al. Genome Res, 2004 Apr. PMID 15060004, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ribonuclease P RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ribonuclease P activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA 5'-leader removal ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of multimeric ribonuclease P complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ribonuclease P protein subunit p21
    Names
    ribonuclease P 21 subunit
    ribonuclease P 21kDa subunit
    ribonuclease P/MRP 21 subunit
    NP_001002831.1
    XP_063135447.1
    XP_063135448.1
    XP_063135449.1
    XP_063135450.1
    XP_063135451.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002831.1 → NP_001002831.1  ribonuclease P protein subunit p21

      See identical proteins and their annotated locations for NP_001002831.1

      Status: PROVISIONAL

      Source sequence(s)
      BX883050
      UniProtKB/TrEMBL
      Q6MFZ6
      Related
      ENSRNOP00000098165.1, ENSRNOT00000120507.2
      Conserved Domains (1) summary
      pfam04032
      Location:13 → 96
      Rpr2; RNAse P Rpr2/Rpp21/SNM1 subunit domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      1986225..2025308
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279377.1 → XP_063135447.1  ribonuclease P protein subunit p21 isoform X1

    2. XM_063279378.1 → XP_063135448.1  ribonuclease P protein subunit p21 isoform X2

    3. XM_063279381.1 → XP_063135451.1  ribonuclease P protein subunit p21 isoform X4

    4. XM_063279379.1 → XP_063135449.1  ribonuclease P protein subunit p21 isoform X3

    5. XM_063279380.1 → XP_063135450.1  ribonuclease P protein subunit p21 isoform X3

      Related
      ENSRNOP00000094860.3, ENSRNOT00000118924.3
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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