Map1b microtubule-associated protein 1B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Map1bprovided by RGD
Official Full Name: microtubule-associated protein 1Bprovided by RGD
Primary source: RGD:3043
See related: EnsemblRapid:ENSRNOG00000017428 AllianceGenome:RGD:3043
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mtap1b
Summary: Enables actin binding activity; microtubule binding activity; and phospholipid binding activity. Involved in several processes, including nervous system development; positive regulation of cell differentiation; and regulation of microtubule polymerization or depolymerization. Located in several cellular components, including axon; dendrite; and perikaryon. Part of microtubule associated complex. Biomarker of hypothyroidism and visual epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 83 and periventricular nodular heterotopia. Orthologous to human MAP1B (microtubule associated protein 1B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 1000.6), Heart (RPKM 118.4) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (32551423..32644471, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (30817261..30910458, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (29675391..29768750, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This work confirms a new biological role of MAP1B in the regulation of sodium channel localization
Title: The MAP1B Binding Domain of Na(v)1.6 Is Required for Stable Expression at the Axon Initial Segment.
MAP1B restricts the access of AMPARs to dendritic spines and the postsynaptic membrane, contributing to downregulating synaptic transmission
Title: MAP1B Light Chain Modulates Synaptic Transmission via AMPA Receptor Intracellular Trapping.
MAP1B interacts with a guanine exchange factor, termed Tiam1, which specifically activates Rac1. a novel function of MAP1B related with the control of small GTPases
Title: The light chain 1 subunit of the microtubule-associated protein 1B (MAP1B) is responsible for Tiam1 binding and Rac1 activation in neuronal cells.
Overexpression of MAP1B 1-126 induced both neurite extension and neuronal death, suggesting that MAP1B 1-126 could be involved in neuronal degeneration and aberrant sprouting.
Title: MAP1B 1-126 interacts with tubulin isoforms and induces neurite outgrowth and neuronal death of cultured cortical neurons.
MAP1B enhances microtubule assembly rates and axon extension rates in developing neurons by binding to dynamic microtubules.
Title: MAP1B enhances microtubule assembly rates and axon extension rates in developing neurons.
We suggest a role for Stau2 in the generation and regulation of Map1b mRNA containing granules that are required for mGluR-long-term depression
Title: Staufen 2 regulates mGluR long-term depression and Map1b mRNA distribution in hippocampal neurons.
Results provide marker proteins Gap-43 and newly identified candidate neuronal growth-associated proteins MAP1B, CRMP5, crmp5 and catenins.
Title: Identification of functional marker proteins in the mammalian growth cone.
Data report that Bcl11A downregulates axon branching, and that the expression of DCC and MAP1b, two molecules involved in direction and branching of axon outgrowth, is controlled by Bcl11A-L.
Title: Bcl11A/CTIP1 regulates expression of DCC and MAP1b in control of axon branching and dendrite outgrowth.
Nonprimed and DYRK1A-primed GSK3 beta-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons.
Title: Nonprimed and DYRK1A-primed GSK3 beta-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons.
The light chain (LC1) of microtubule-associated protein 1B (MAP1B)-5-HT(3A) receptor interaction contributes to a mechanism that regulates receptor desensitization kinetics.
Title: Modulation of 5-HT3 receptor desensitization by the light chain of microtubule-associated protein 1B expressed in HEK 293 cells.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mtap1b (e-PCR), detects polymorphism
- UniSTS:143927

Mtap5 (e-PCR)
- UniSTS:143928

UniSTS:143928 (e-PCR)
- UniSTS:143928

X51396 (e-PCR)
- UniSTS:160337

RH137448 (e-PCR)
- UniSTS:219536

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables phospholipid binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon extension	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to peptide hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in dendrite development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dendrite development	ISO Inferred from Sequence Orthology more info
involved_in developmental maturation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within establishment of monopolar cell polarity	ISO Inferred from Sequence Orthology more info
involved_in induction of synaptic plasticity by chemical substance	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of intracellular transport	ISO Inferred from Sequence Orthology more info
involved_in microtubule bundle formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within microtubule bundle formation	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrion transport along microtubule	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of intracellular transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuron development	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within odontoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in peripheral nervous system axon regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of microtubule polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in response to axon injury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to carbohydrate	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insecticide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in synapse assembly	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in apical dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in basal dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in hippocampal mossy fiber	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
part_of microtubule associated complex	IBA Inferred from Biological aspect of Ancestor more info
part_of microtubule associated complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in somatodendritic compartment	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in varicosity	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: microtubule-associated protein 1B

Names: MAP-1B; neuraxin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019217.1 → NP_062090.1 microtubule-associated protein 1B

Status: PROVISIONAL

Source sequence(s)

AA925503, BF286433, BG378086, BG665276, CA503854, CA510735, CA510940, CB576609, CB579120, CB580055, CB583564, CB584802, CB610210, CB810012, CF977184, CO393350, X60370

UniProtKB/Swiss-Prot

B0BNK3, F1LRL9, P15205, Q62958, Q9ER21, Q9QW92

Related

ENSRNOP00000023460.6, ENSRNOT00000023460.7

Conserved Domains (3) summary

PTZ00121
Location:531 → 1158

PTZ00121; MAEBL; Provisional

PHA03247
Location:2095 → 2348

PHA03247; large tegument protein UL36; Provisional

pfam05109
Location:1543 → 1875

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

32551423..32644471 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101889.2 → XP_038957817.1 microtubule-associated protein 1B isoform X1

UniProtKB/Swiss-Prot

B0BNK3, F1LRL9, P15205, Q62958, Q9ER21, Q9QW92

UniProtKB/TrEMBL

A6I569

Conserved Domains (3) summary

PTZ00121
Location:405 → 1032

PTZ00121; MAEBL; Provisional

PHA03247
Location:1969 → 2222

PHA03247; large tegument protein UL36; Provisional

pfam05109
Location:1417 → 1749

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)