Cers2 ceramide synthase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cers2provided by RGD
Official Full Name: ceramide synthase 2provided by RGD
Primary source: RGD:1310059
See related: EnsemblRapid:ENSRNOG00000021138 AllianceGenome:RGD:1310059
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lass2
Summary: Predicted to enable sphingosine N-acyltransferase activity. Involved in several processes, including negative regulation of Schwann cell migration; negative regulation of Schwann cell proliferation involved in axon regeneration; and negative regulation of axon regeneration. Predicted to be located in endoplasmic reticulum. Biomarker of sciatic neuropathy. Orthologous to human CERS2 (ceramide synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 637.0), Lung (RPKM 320.5) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 2q34

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (185579511..185587789)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (182890527..182898805)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (196487656..196495930)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sciatic nerve injury promotes Schwann cell proliferation and migration through the regulation of miR-221/222 by targeting LASS2
Title: miR-221 and miR-222 promote Schwann cell proliferation and migration by targeting LASS2 after sciatic nerve injury.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

UniSTS:234764 (e-PCR)
- UniSTS:234764

AW535103 (e-PCR)
- UniSTS:247178

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables N-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables sphingosine N-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingosine N-acyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ceramide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Schwann cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Schwann cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Schwann cell proliferation involved in axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sphingolipid biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: ceramide synthase 2

Names: LAG1 homolog, ceramide synthase 2

NP_001028872.2

EC 2.3.1.24

XP_006232949.1

EC 2.3.1.24

XP_006232950.1

EC 2.3.1.24

XP_038958282.1

EC 2.3.1.24

XP_038958283.1

EC 2.3.1.24

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033700.2 → NP_001028872.2 ceramide synthase 2

See identical proteins and their annotated locations for NP_001028872.2

Status: VALIDATED

Source sequence(s)

BC101876, BI284504, CF110567, CK365108

UniProtKB/TrEMBL

A6K2Y5, G3V8V4, Q3T1K1

Related

ENSRNOP00000028699.2, ENSRNOT00000028699.6

Conserved Domains (2) summary

smart00724
Location:131 → 332

TLC; TRAM, LAG1 and CLN8 homology domains

cd00086
Location:71 → 128

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

185579511..185587789

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006232888.4 → XP_006232950.1 ceramide synthase 2 isoform X1

See identical proteins and their annotated locations for XP_006232950.1

UniProtKB/TrEMBL

A6K2Y5, G3V8V4, Q3T1K1

Conserved Domains (2) summary

smart00724
Location:131 → 332

TLC; TRAM, LAG1 and CLN8 homology domains

cd00086
Location:71 → 128

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
XM_039102355.2 → XP_038958283.1 ceramide synthase 2 isoform X1

UniProtKB/TrEMBL

A6K2Y5, G3V8V4, Q3T1K1

Conserved Domains (2) summary

smart00724
Location:131 → 332

TLC; TRAM, LAG1 and CLN8 homology domains

cd00086
Location:71 → 128

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
XM_039102354.2 → XP_038958282.1 ceramide synthase 2 isoform X1

UniProtKB/TrEMBL

A6K2Y5, G3V8V4, Q3T1K1

Conserved Domains (2) summary

smart00724
Location:131 → 332

TLC; TRAM, LAG1 and CLN8 homology domains

cd00086
Location:71 → 128

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
XM_006232887.5 → XP_006232949.1 ceramide synthase 2 isoform X1

See identical proteins and their annotated locations for XP_006232949.1

UniProtKB/TrEMBL

A6K2Y5, G3V8V4, Q3T1K1

Conserved Domains (2) summary

smart00724
Location:131 → 332

TLC; TRAM, LAG1 and CLN8 homology domains

cd00086
Location:71 → 128

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.