Rasd2 RASD family, member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rasd2provided by RGD
Official Full Name: RASD family, member 2provided by RGD
Primary source: RGD:628594
See related: EnsemblRapid:ENSRNOG00000014761 AllianceGenome:RGD:628594
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rhes
Summary: Enables GTP binding activity; phosphatidylinositol 3-kinase binding activity; and ubiquitin conjugating enzyme binding activity. Involved in negative regulation of protein ubiquitination; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of protein sumoylation. Located in plasma membrane. Orthologous to human RASD2 (RASD family member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 134.4), Uterus (RPKM 75.9) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (13600028..13610753)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (13594291..13605016)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (14653198..14663914)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rhes robustly binds the autophagy regulator Beclin-1, decreasing its inhibitory interaction with Bcl-2 independent of JNK-1 signaling.
Title: Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy.
Rhes is a novel striatal regulator of the AKT-mediated pathway in the striatum.
Title: Striatum specific protein, Rhes regulates AKT pathway.
study reports Rhes, which is localized selectively to the striatum, binds to mutant huntingtin (mHtt); Rhes induces sumoylation of mHtt leading to cytotoxicity; Rhes-mHtt interactions can account for the localized neuropathology of Huntington disease
Title: Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity.
Data show that Rhes mRNA is expressed at high levels in hippocampus and cerebellum during the postnatal period.
Title: Ontogeny and dopaminergic regulation in brain of Ras homolog enriched in striatum (Rhes).
role in signal transduction of this novel Ras family member
Title: The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors.
These findings suggest that rhes mRNA expression is maintained by dopamine and may play a role in determining normal dopamine receptor sensitivity.
Title: Rhes, the Ras homolog enriched in striatum, is reduced under conditions of dopamine supersensitivity.

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General gene information

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Markers

RH130539 (e-PCR)
- UniSTS:213823

BF403282 (e-PCR)
- UniSTS:246374

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-protein beta-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta-subunit binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin conjugating enzyme binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, dopaminergic	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GTP-binding protein Rhes

Names: SE6C; ras homolog enriched in striatum

NP_598252.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133568.2 → NP_598252.1 GTP-binding protein Rhes

See identical proteins and their annotated locations for NP_598252.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

P63033

UniProtKB/TrEMBL

A6JYA0

Related

ENSRNOP00000020017.2, ENSRNOT00000020017.5

Conserved Domains (1) summary

cd04143
Location:20 → 266

Rhes_like; Ras homolog enriched in striatum (Rhes) and activator of G-protein signaling 1 (Dexras1/AGS1)