Cideb cell death-inducing DFFA-like effector b [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cidebprovided by RGD
Official Full Name: cell death-inducing DFFA-like effector bprovided by RGD
Primary source: RGD:1310000
See related: EnsemblRapid:ENSRNOG00000020377 AllianceGenome:RGD:1310000
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including identical protein binding activity; lipid transfer activity; and phosphatidic acid binding activity. Involved in response to nutrient levels. Predicted to be located in cytosol and perinuclear region of cytoplasm. Predicted to be part of COPII vesicle coat. Predicted to be active in Golgi apparatus; endoplasmic reticulum membrane; and lipid droplet. Orthologous to human CIDEB (cell death inducing DFFA like effector b). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 442.3) and Kidney (RPKM 155.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (33222135..33226407, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (29252208..29256482, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (34439844..34444244, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CideB protein is required for the biogenesis of very low density lipoprotein (VLDL) transport vesicle
Title: CideB protein is required for the biogenesis of very low density lipoprotein (VLDL) transport vesicle.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid transfer activity	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables phosphatidic acid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in COPII-coated vesicle cargo loading	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
involved_in lipid droplet fusion	ISO Inferred from Sequence Orthology more info
involved_in lipid storage	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in very-low-density lipoprotein particle assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of COPII vesicle coat	ISO Inferred from Sequence Orthology more info
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lipid transferase CIDEB

Names: cell death activator CIDE-B; cell death-inducing DNA fragmentation factor, alpha subunit-like effector B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399449.1 → NP_001386378.1 lipid transferase CIDEB

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A6KH50, D3ZKI3

Related

ENSRNOP00000027612.5, ENSRNOT00000027612.8

Conserved Domains (1) summary

cd06537
Location:34 → 114

CIDE_N_B; CIDE_N domain of CIDE-B proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

33222135..33226407 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001108869.2: Suppressed sequence

Description

NM_001108869.2: This RefSeq was removed because currently there is insufficient support for the transcript.