Clip2 CAP-GLY domain containing linker protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Clip2provided by RGD
Official Full Name: CAP-GLY domain containing linker protein 2provided by RGD
Primary source: RGD:62019
See related: EnsemblRapid:ENSRNOG00000021611 AllianceGenome:RGD:62019
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyln2; CLIP-115
Summary: Enables microtubule plus-end binding activity. Predicted to be involved in cytoplasmic microtubule organization. Located in cytoplasmic microtubule; dendritic microtubule; and lamellar body. Orthologous to human CLIP2 (CAP-Gly domain containing linker protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 170.8), Lung (RPKM 71.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (27798289..27863486)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (22163044..22227023)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (25172957..25236935)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CLIPs enable neuronal polarization by controlling the stabilization of microtubules and growth cone dynamics.
Title: Cytoplasmic linker proteins regulate neuronal polarization through microtubule and growth cone dynamics.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137562 (e-PCR)
- UniSTS:219649

RH139152 (e-PCR)
- UniSTS:221238

AU048698 (e-PCR)
- UniSTS:145148

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	TAS Traceable Author Statement more info	PubMed
enables microtubule plus-end binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule plus-end binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule plus-end binding	IEA Inferred from Electronic Annotation more info
enables microtubule plus-end binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of microtubule depolymerization	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	TAS Traceable Author Statement more info	PubMed
located_in dendritic microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in lamellar body	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in microtubule plus-end	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule plus-end	IEA Inferred from Electronic Annotation more info
located_in microtubule plus-end	ISO Inferred from Sequence Orthology more info
located_in microtubule plus-end	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CAP-Gly domain-containing linker protein 2

Names: cytoplasmic linker 2; cytoplasmic linker protein 115; cytoplasmic linker protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021997.2 → NP_068837.2 CAP-Gly domain-containing linker protein 2

See identical proteins and their annotated locations for NP_068837.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

O55156

UniProtKB/TrEMBL

A6J0J0, G3V949

Related

ENSRNOP00000035734.3, ENSRNOT00000033200.6

Conserved Domains (2) summary

COG1196
Location:357 → 1016

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam01302
Location:222 → 286

CAP_GLY; CAP-Gly domain