Ervfrd-1 endogenous retrovirus group FRD member 1, envelope [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ervfrd-1provided by RGD
Official Full Name: endogenous retrovirus group FRD member 1, envelopeprovided by RGD
Primary source: RGD:1563240
See related: EnsemblRapid:ENSRNOG00000050672 AllianceGenome:RGD:1563240
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gm52; Syna
Summary: Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of a endogenous retrovirus provirus on rat chromosome 12 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Apr 2015]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: 12q12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (27787680..27794732)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (22151211..22158264)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (25161130..25168182)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Syna (e-PCR), detects polymorphism
- UniSTS:548131

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within labyrinthine layer development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myoblast fusion	ISO Inferred from Sequence Orthology more info
involved_in syncytium formation	ISO Inferred from Sequence Orthology more info
involved_in syncytium formation by plasma membrane fusion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within syncytium formation by plasma membrane fusion	ISO Inferred from Sequence Orthology more info
involved_in syncytium formation by plasma membrane fusion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: envelope glycoprotein syncytin-A

Names: syncytin a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014771.2 → NP_001014771.1 envelope glycoprotein syncytin-A precursor

See identical proteins and their annotated locations for NP_001014771.1

Status: REVIEWED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

Q5G5D4

Related

ENSRNOP00000067387.1, ENSRNOT00000074788.3

Conserved Domains (1) summary

cd09851
Location:446 → 523

HTLV-1-like_HR1-HR2; heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of human T-cell leukemia virus type 1 (HTLV-1), and related domains