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    Nle1 notchless homolog 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303372, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Nle1provided by RGD
    Official Full Name
    notchless homolog 1provided by RGD
    Primary source
    RGD:1308301
    See related
    EnsemblRapid:ENSRNOG00000008287 AllianceGenome:RGD:1308301
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308301
    Summary
    Predicted to be involved in regulation of Notch signaling pathway. Predicted to act upstream of or within several processes, including chordate embryonic development; hematopoietic stem cell homeostasis; and positive regulation of canonical Wnt signaling pathway. Predicted to be located in nucleoplasm. Predicted to be active in nucleolus. Orthologous to human NLE1 (notchless homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 55.5), Muscle (RPKM 41.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nle1 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (68331609..68342562, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (67834059..67844771, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (70250959..70261880, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene RAD51 paralog D Neighboring gene U6 spliceosomal RNA Neighboring gene fibronectin type III domain containing 8 Neighboring gene unc-45 myosin chaperone B Neighboring gene schlafen family member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ENU mutagenesis reveals that Notchless homolog 1 (Drosophila) affects Cdkn1a and several members of the Wnt pathway during murine pre-implantation development. Lossie AC, et al. BMC Genet, 2012 Dec 12. PMID 23231322, Free PMC Article
    2. Elevated CXCL1 expression in gp130-deficient endothelial cells impairs neutrophil migration in mice. Yao L, et al. Blood, 2013 Nov 28. PMID 24081661, Free PMC Article
    3. The murine ortholog of notchless, a direct regulator of the notch pathway in Drosophila melanogaster, is essential for survival of inner cell mass cells. Cormier S, et al. Mol Cell Biol, 2006 May. PMID 16611995, Free PMC Article
    4. Notchless-dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells. Le Bouteiller M, et al. J Exp Med, 2013 Oct 21. PMID 24062412, Free PMC Article
    5. Notchless is required for axial skeleton formation in mice. Beck-Cormier S, et al. PLoS One, 2014. PMID 24875805, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hematopoietic stem cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inner cell mass cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ribosomal large subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within somitogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    notchless protein homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127534.1 → NP_001121006.1  notchless protein homolog 1

      See identical proteins and their annotated locations for NP_001121006.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166567
      UniProtKB/TrEMBL
      B2GV82, F7FIP9
      Related
      ENSRNOP00000011320.7, ENSRNOT00000011320.8
      Conserved Domains (4) summary
      COG2319
      Location:109 → 487
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:108 → 486
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08154
      Location:19 → 79
      NLE; NLE (NUC135) domain
      sd00039
      Location:161 → 199
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      68331609..68342562 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246995.5 → XP_006247057.1  notchless protein homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_006247057.1

      UniProtKB/TrEMBL
      B2GV82, F7FIP9
      Conserved Domains (4) summary
      COG2319
      Location:109 → 487
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:108 → 486
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08154
      Location:19 → 79
      NLE; NLE (NUC135) domain
      sd00039
      Location:161 → 199
      7WD40; WD40 repeat [structural motif]

    2. XM_006246994.5 → XP_006247056.1  notchless protein homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_006247056.1

      UniProtKB/TrEMBL
      B2GV82, F7FIP9
      Conserved Domains (4) summary
      COG2319
      Location:109 → 487
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:108 → 486
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08154
      Location:19 → 79
      NLE; NLE (NUC135) domain
      sd00039
      Location:161 → 199
      7WD40; WD40 repeat [structural motif]

    3. XM_063269084.1 → XP_063125154.1  notchless protein homolog 1 isoform X2

    4. XM_063269085.1 → XP_063125155.1  notchless protein homolog 1 isoform X2

    RNA

    1. XR_010055183.1 RNA Sequence

    2. XR_010055182.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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