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    Leap2 liver enriched antimicrobial peptide 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497901, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Leap2provided by RGD
    Official Full Name
    liver enriched antimicrobial peptide 2provided by RGD
    Primary source
    RGD:1561235
    See related
    EnsemblRapid:ENSRNOG00000007218 AllianceGenome:RGD:1561235
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ac1177
    Summary
    Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 2663.1), Adrenal (RPKM 2526.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Leap2 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (38081001..38082073, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (37580172..37581244, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (38771125..38774515, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ALF transcription elongation factor 4 Neighboring gene ribosomal protein L10, pseudogene 1 Neighboring gene uncharacterized LOC134480791 Neighboring gene ubiquinol-cytochrome c reductase, complex III subunit VII Neighboring gene growth differentiation factor 9 Neighboring gene shroom family member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Study of the Ghrelin/LEAP-2 Ratio in Humans and Rats during Different Phases of Pregnancy. Garcés MF, et al. Int J Mol Sci, 2022 Aug 23. PMID 36076912, Free PMC Article
    2. LEAP-2 Counteracts Ghrelin-Induced Food Intake in a Nutrient, Growth Hormone and Age Independent Manner. Lugilde J, et al. Cells, 2022 Jan 19. PMID 35159134, Free PMC Article
    3. Isolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver. Krause A, et al. Protein Sci, 2003 Jan. PMID 12493837, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study of the Ghrelin/LEAP-2 Ratio in Humans and Rats during Different Phases of Pregnancy.
      Title: Study of the Ghrelin/LEAP-2 Ratio in Humans and Rats during Different Phases of Pregnancy.
    2. LEAP-2 Counteracts Ghrelin-Induced Food Intake in a Nutrient, Growth Hormone and Age Independent Manner.
      Title: LEAP-2 Counteracts Ghrelin-Induced Food Intake in a Nutrient, Growth Hormone and Age Independent Manner.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    liver-expressed antimicrobial peptide 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393341.1 → NP_001380270.1  liver-expressed antimicrobial peptide 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6AA59, A6HEC5, Q5M9I7
      Related
      ENSRNOP00000088778.1, ENSRNOT00000098404.2
      Conserved Domains (1) summary
      pfam07359
      Location:1 → 76
      LEAP-2; Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      38081001..38082073 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001126081.1: Suppressed sequence

      Description
      NM_001126081.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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