Mcam melanoma cell adhesion molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mcamprovided by RGD
Official Full Name: melanoma cell adhesion moleculeprovided by RGD
Primary source: RGD:620463
See related: EnsemblRapid:ENSRNOG00000007726 AllianceGenome:RGD:620463
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CD146; Muc18
Summary: Involved in positive regulation of cell migration. Located in extracellular space. Biomarker of impotence and malignant mesothelioma. Orthologous to human MCAM (melanoma cell adhesion molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 474.8), Heart (RPKM 232.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (53376225..53384407)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (44479391..44487575)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (48472824..48481005)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Menstrual blood CD146(+) mesenchymal stem cells reduced fibrosis rate in the rat model of premature ovarian failure.
Title: Menstrual blood CD146(+) mesenchymal stem cells reduced fibrosis rate in the rat model of premature ovarian failure.
CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-alpha4.
Title: CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4.
Expression of cell adhesion molecule, Gicerin/CD146 during the formation of heart and in the cardiac hypertrophy.
Title: Expression of cell adhesion molecule, Gicerin/CD146 during the formation of heart and in the cardiac hypertrophy.
Alterations in CD146 are involved in the basic etiology of COPD/pulmonary emphysema.
Title: Endothelial cell adhesion molecule CD146: implications for its role in the pathogenesis of COPD.
Gicerin might promote the interaction of tumor cells with a hepatic endothelium, thus leading to the hepatic metastasis of colon adenocarcinomas.
Title: Involvement of gicerin, a cell adhesion molecule, in the portal metastasis of rat colorectal adenocarcinoma cells.
Increase of gicerin expression by NGF promotes the gicerin-gicerin homophilic interaction resulting in the neurite extension.
Title: Gicerin/CD146 is involved in neurite extension of NGF-treated PC12 cells.
expression of gicerin was increased in the rat carotid arteries after balloon injury. Gicerin might be involved in the arteriosclerotic neointima formation in the artery.
Title: Induction of gicerin/CD146 in the rat carotid artery after balloon injury.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables laminin receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in glomerular filtration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in vascular wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cell surface glycoprotein MUC18

Names: gicerin; l-gicerin; melanoma-associated antigen MUC18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034009.1 → NP_001029181.1 cell surface glycoprotein MUC18 isoform 2 precursor

See identical proteins and their annotated locations for NP_001029181.1

Status: VALIDATED

Source sequence(s)

BC070916

UniProtKB/TrEMBL

A0A8I6AFJ0, A6J3W1

Related

ENSRNOP00000069860.1, ENSRNOT00000090780.3

Conserved Domains (4) summary

pfam08205
Location:141 → 236

C2-set_2; CD80-like C2-set immunoglobulin domain

pfam13927
Location:348 → 412

Ig_3; Immunoglobulin domain

cd00096
Location:172 → 177

Ig; Ig strand C [structural motif]

cl11960
Location:452 → 508

Ig; Immunoglobulin domain
NM_023983.3 → NP_076473.2 cell surface glycoprotein MUC18 isoform 1 precursor

See identical proteins and their annotated locations for NP_076473.2

Status: VALIDATED

Source sequence(s)

AB035506, BC070916

UniProtKB/Swiss-Prot

Q6IRH8, Q9EPF2, Q9ESS8

UniProtKB/TrEMBL

A0A8I6AFJ0, A6J3W0

Related

ENSRNOP00000010464.5, ENSRNOT00000010463.8

Conserved Domains (4) summary

smart00408
Location:359 → 412

IGc2; Immunoglobulin C-2 Type

smart00410
Location:440 → 515

IG_like; Immunoglobulin like

pfam08205
Location:141 → 236

C2-set_2; CD80-like C2-set immunoglobulin domain

cl11960
Location:452 → 515

Ig; Immunoglobulin domain