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    Ncbp1 nuclear cap binding protein subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298075, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ncbp1provided by RGD
    Official Full Name
    nuclear cap binding protein subunit 1provided by RGD
    Primary source
    RGD:1308973
    See related
    EnsemblRapid:ENSRNOG00000023605 AllianceGenome:RGD:1308973
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA 7-methylguanosine cap binding activity; mRNA binding activity; and molecular adaptor activity. Predicted to be involved in several processes, including RNA export from nucleus; mRNA metabolic process; and positive regulation of mRNA processing. Part of nuclear cap binding activity complex. Orthologous to human NCBP1 (nuclear cap binding protein subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Kidney (RPKM 305.3), Thymus (RPKM 221.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ncbp1 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (65211632..65244532)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (60416023..60449004)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (61734118..61767098)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102866 Neighboring gene tudor domain containing 7 Neighboring gene tropomodulin 1 Neighboring gene thiosulfate sulfurtransferase like domain containing 2 Neighboring gene XPA, DNA damage recognition and repair factor Neighboring gene sorbitol dehydrogenase, pseudogene 4 Neighboring gene forkhead box E1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC105807

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding PubMed 
    enables RNA 7-methylguanosine cap binding  
    enables RNA cap binding  
    enables RNA cap binding  
    enables mRNA binding  
    enables molecular adaptor activity  
    Items 1 - 25 of 30
    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping  
    involved_in 7-methylguanosine mRNA capping  
    involved_in 7-methylguanosine mRNA capping  
    involved_in RNA catabolic process  
    involved_in RNA metabolic process  
    involved_in RNA splicing  
    involved_in biological_process  
    involved_in defense response to virus  
    involved_in histone mRNA metabolic process  
    involved_in mRNA export from nucleus  
    involved_in mRNA export from nucleus  
    involved_in mRNA export from nucleus  
    involved_in mRNA export from nucleus  
    involved_in mRNA metabolic process  
    involved_in mRNA metabolic process  
    involved_in mRNA transcription by RNA polymerase II  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of mRNA 3'-end processing  
    involved_in positive regulation of mRNA 3'-end processing  
    involved_in positive regulation of mRNA splicing, via spliceosome  
    involved_in regulation of mRNA processing  
    involved_in regulation of translational initiation  
    involved_in regulation of translational initiation  
    involved_in regulatory ncRNA-mediated gene silencing  
    involved_in snRNA export from nucleus  
    involved_in spliceosomal complex assembly  
    Items 1 - 25 of 30
    Component Evidence Code Pubs
    part_of RNA cap binding complex  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in mitochondrion  
    located_in mitochondrion  
    part_of nuclear cap binding complex  
    part_of nuclear cap binding complex PubMed 
    part_of nuclear cap binding complex  
    part_of nuclear cap binding complex  
    part_of nuclear cap binding complex  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in nucleus  
    part_of ribonucleoprotein complex  
    part_of ribonucleoprotein complex  

    General protein information

    Preferred Names
    nuclear cap-binding protein subunit 1
    Names
    80 kDa nuclear cap-binding protein
    CBP80
    NCBP 80 kDa subunit
    nuclear cap binding protein subunit 1, 80kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014785.1NP_001014785.1  nuclear cap-binding protein subunit 1

      See identical proteins and their annotated locations for NP_001014785.1

      Status: PROVISIONAL

      Source sequence(s)
      BC092199
      UniProtKB/Swiss-Prot
      Q56A27
      UniProtKB/TrEMBL
      A0A8I6GF54, A6IJB1
      Related
      ENSRNOP00000077595.1, ENSRNOT00000109965.2
      Conserved Domains (3) summary
      smart00543
      Location:28240
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam09088
      Location:351470
      MIF4G_like; MIF4G like
      pfam09090
      Location:485760
      MIF4G_like_2; MIF4G like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      65211632..65244532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238037.4XP_006238099.1  nuclear cap-binding protein subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GF54
      Conserved Domains (3) summary
      smart00543
      Location:1133
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam09088
      Location:244363
      MIF4G_like; MIF4G like
      pfam09090
      Location:378653
      MIF4G_like_2; MIF4G like
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