Slc12a4 solute carrier family 12 member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc12a4provided by RGD
Official Full Name: solute carrier family 12 member 4provided by RGD
Primary source: RGD:3687
See related: EnsemblRapid:ENSRNOG00000019651 AllianceGenome:RGD:3687
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kcc1
Summary: Predicted to enable ATP binding activity; potassium:chloride symporter activity; and protein kinase binding activity. Predicted to be involved in several processes, including chloride ion homeostasis; monoatomic ion transmembrane transport; and potassium ion homeostasis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human SLC12A4 (solute carrier family 12 member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 124.9), Heart (RPKM 120.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (50748268..50770217, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (33838418..33860369, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (37917003..37938952, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KCC1 affects water transport solely by K(+) extrusion. Intracellular K(+) retention conceivably leads to cell swelling, followed by an increased rate of endocytic AQP2 retrieval from the apical membrane.
Title: Routes of epithelial water flow: aquaporins versus cotransporters.
distribution of KCC1, KCC3a, KCC3b, KCC4, and KCC2 protein and mrna in pancreatic alpha-cells and beta-cells; KCC's make a significant contribution to volume homeostasis only in alpha-cells
Title: Expression of K+-Cl- cotransporters in the alpha-cells of rat endocrine pancreas.
KCC1 is expressed in olfactory epithelium and participates in generation of the excitatory receptor current.
Title: Chloride accumulation in mammalian olfactory sensory neurons.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134132 (e-PCR)
- UniSTS:217414

RH44404 (e-PCR)
- UniSTS:48741

RH77895 (e-PCR)
- UniSTS:34407

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables potassium:chloride symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium:chloride symporter activity	IEA Inferred from Electronic Annotation more info
enables potassium:chloride symporter activity	ISO Inferred from Sequence Orthology more info
enables potassium:chloride symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell volume homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 12 member 4

Names: electroneutral potassium-chloride cotransporter 1; erythroid K-Cl cotransporter 1; furosemide-sensitive K-Cl cotransporter; rKCC1; solute carrier family 12 (potassium/chloride transporter), member 4; solute carrier family 12 (potassium/chloride transporters), member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019229.2 → NP_062102.1 solute carrier family 12 member 4

See identical proteins and their annotated locations for NP_062102.1

Status: PROVISIONAL

Source sequence(s)

U55815

UniProtKB/Swiss-Prot

P70632, Q63632

UniProtKB/TrEMBL

A6IYV0

Related

ENSRNOP00000026730.3, ENSRNOT00000026730.6

Conserved Domains (3) summary

TIGR00930
Location:42 → 1085

2a30; K-Cl cotransporter

pfam03522
Location:709 → 1085

SLC12; Solute carrier family 12

cl00456
Location:142 → 303

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

50748268..50770217 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008772492.4 → XP_008770714.1 solute carrier family 12 member 4 isoform X3

Conserved Domains (3) summary

TIGR00930
Location:63 → 1080

2a30; K-Cl cotransporter

pfam03522
Location:704 → 1080

SLC12; Solute carrier family 12

cl00456
Location:137 → 298

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006255482.5 → XP_006255544.1 solute carrier family 12 member 4 isoform X1

UniProtKB/TrEMBL

A0A8I5ZKL7

Related

ENSRNOP00000078286.1, ENSRNOT00000095105.2

Conserved Domains (3) summary

TIGR00930
Location:11 → 1054

2a30; K-Cl cotransporter

pfam03522
Location:678 → 1054

SLC12; Solute carrier family 12

cl00456
Location:111 → 272

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_039097677.2 → XP_038953605.1 solute carrier family 12 member 4 isoform X2

Conserved Domains (1) summary

TIGR00930
Location:42 → 583

2a30; K-Cl cotransporter