ANGPTL4 angiopoietin like 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ANGPTL4provided by HGNC
Official Full Name: angiopoietin like 4provided by HGNC
Primary source: HGNC:HGNC:16039
See related: Ensembl:ENSG00000167772 MIM:605910; AllianceGenome:HGNC:16039
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NL2; ARP4; FIAF; HARP; PGAR; HFARP; TGQTL; UNQ171; pp1158
Summary: This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]
Expression: Broad expression in liver (RPKM 42.4), fat (RPKM 23.7) and 17 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (8364155..8374370)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (8350623..8360841)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (8429039..8439254)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Correlation between serum ANGPTL4 levels and white matter hyperintensity and cognitive impairment in patients with cerebral small vessel disease.
Title: Correlation between serum ANGPTL4 levels and white matter hyperintensity and cognitive impairment in patients with cerebral small vessel disease.
ANGPTL4 plays a paradoxical role in gastric cancer through the LGALS7 and Hedgehog pathways.
Title: ANGPTL4 plays a paradoxical role in gastric cancer through the LGALS7 and Hedgehog pathways.
ANGPTL4 Suppresses Clear Cell Renal Cell Carcinoma via Inhibition of Lysosomal Acid Lipase.
Title: ANGPTL4 Suppresses Clear Cell Renal Cell Carcinoma via Inhibition of Lysosomal Acid Lipase.
Impact of loss-of-function in angiopoietin-like 4 on the human phenome.
Title: Impact of loss-of-function in angiopoietin-like 4 on the human phenome.
Renal lipid accumulation and aging linked to tubular cells injury via ANGPTL4.
Title: Renal lipid accumulation and aging linked to tubular cells injury via ANGPTL4.
Characterization of sexual dimorphism in ANGPTL4 levels and function.
Title: Characterization of sexual dimorphism in ANGPTL4 levels and function.
Attenuating Epithelial-to-Mesenchymal Transition in Cancer through Angiopoietin-Like 4 Inhibition in a 3D Tumor Microenvironment Model.
Title: Attenuating Epithelial-to-Mesenchymal Transition in Cancer through Angiopoietin-Like 4 Inhibition in a 3D Tumor Microenvironment Model.
T266M variants of ANGPTL4 improve lipid metabolism by modifying their binding affinity to acetyl-CoA carboxylase in obstructive sleep apnea.
Title: T266M variants of ANGPTL4 improve lipid metabolism by modifying their binding affinity to acetyl-CoA carboxylase in obstructive sleep apnea.
Correlation between the serum FABP4, ANGPTL3, and ANGPTL4 levels and coronary artery disease.
Title: Correlation between the serum FABP4, ANGPTL3, and ANGPTL4 levels and coronary artery disease.
Correlation of serum VEGF-C, ANGPTL4, and activin A levels with frailty.
Title: Correlation of serum VEGF-C, ANGPTL4, and activin A levels with frailty.

Submit: New GeneRIF Correction See all GeneRIFs (239)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Plasma triglyceride level quantitative trait locus MedGen: C4014553 OMIM: 615881 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids. EBI GWAS Catalog EBI GWAS CatalogPubMed
Common variants at 30 loci contribute to polygenic dyslipidemia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Discovery and refinement of loci associated with lipid levels. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G32455 (e-PCR)
- UniSTS:117040

PMC85983P1 (e-PCR)
- UniSTS:273501

RH11623 (e-PCR)
- UniSTS:31601

ANGPTL4_1969 (e-PCR)
- UniSTS:280440

SHGC-132057 (e-PCR)
- UniSTS:170620

D19S1090 (e-PCR)
- UniSTS:25986

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables enzyme inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of endothelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of lipoprotein lipase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of angiogenesis	TAS Traceable Author Statement more info	PubMed
involved_in protein unfolding	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	NAS Non-traceable Author Statement more info	PubMed
involved_in triglyceride homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride homeostasis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in blood microparticle	HDA more info	PubMed
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: angiopoietin-related protein 4

Names: PPARG angiopoietin related protein; fasting-induced adipose factor; hepatic angiopoietin-related protein; hepatic fibrinogen/angiopoietin-related protein; peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012169.1 RefSeqGene

Range

5029..15244

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001039667.3 → NP_001034756.1 angiopoietin-related protein 4 isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (b) is shorter than isoform a.

Source sequence(s)

AF202636, BP397348

Consensus CDS

CCDS42493.1

UniProtKB/Swiss-Prot

Q9BY76

Related

ENSP00000377534.1, ENST00000393962.6

Conserved Domains (1) summary

cd00087
Location:184 → 362

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
NM_139314.3 → NP_647475.1 angiopoietin-related protein 4 isoform a precursor

See identical proteins and their annotated locations for NP_647475.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AF202636, BP397348

Consensus CDS

CCDS12200.1

UniProtKB/Swiss-Prot

A8MY84, B4E089, D6W670, F5H0I2, Q53HQ6, Q53HU1, Q6UXN0, Q9BY76, Q9HBV4, Q9NZU4, Q9Y5B3

Related

ENSP00000301455.1, ENST00000301455.7

Conserved Domains (1) summary

cd00087
Location:183 → 400

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RNA

NR_104213.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks four internal exons and uses an alternate splice site in the 3' exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.

Source sequence(s)

AC136469

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

8364155..8374370

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005272484.4 → XP_005272541.1 angiopoietin-related protein 4 isoform X1

Conserved Domains (1) summary

cd00087
Location:183 → 418

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
XM_005272485.4 → XP_005272542.1 angiopoietin-related protein 4 isoform X2

Conserved Domains (1) summary

cd00087
Location:184 → 380

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

8350623..8360841

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054321146.1 → XP_054177121.1 angiopoietin-related protein 4 isoform X1
XM_054321147.1 → XP_054177122.1 angiopoietin-related protein 4 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_016109.2: Suppressed sequence

Description

NM_016109.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.