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    ZCCHC14 zinc finger CCHC-type containing 14 [ Homo sapiens (human) ]

    Gene ID: 23174, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZCCHC14provided by HGNC
    Official Full Name
    zinc finger CCHC-type containing 14provided by HGNC
    Primary source
    HGNC:HGNC:24134
    See related
    Ensembl:ENSG00000140948 MIM:620697; AllianceGenome:HGNC:24134
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BDG29; BDG-29
    Summary
    Predicted to enable nucleic acid binding activity; phosphatidylinositol binding activity; and zinc ion binding activity. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 26.9), ovary (RPKM 7.6) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZCCHC14 in Genome Data Viewer
    Location:
    16q24.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (87406248..87493024, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (93477129..93563941, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (87439854..87526630, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene F-box protein 31 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:87417185-87417838 Neighboring gene uncharacterized LOC124903747 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:87417839-87418490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11321 Neighboring gene tRNA-Met (anticodon CAT) 6-1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:87424900-87425858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7837 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11322 Neighboring gene microtubule associated protein 1 light chain 3 beta Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:87440788-87441987 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87456781-87457290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87457291-87457798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87458817-87459326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87460343-87460850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87468667-87469584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87486642-87487142 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:87490779-87491978 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87502852-87503437 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87503438-87504022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87504708-87505665 Neighboring gene nuclear receptor subfamily 3 group C member 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7838 Neighboring gene ZCCHC14 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87552465-87553062 Neighboring gene uncharacterized LOC124903748 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:87573595-87573826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87575434-87575934

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A mega-analysis of genome-wide association studies for major depressive disorder.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger, CCHC domain containing 14 (ZCCHC14) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC14139, MGC126527

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger CCHC domain-containing protein 14
    Names
    zinc finger, CCHC domain containing 14

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015144.3NP_055959.2  zinc finger CCHC domain-containing protein 14

      Status: VALIDATED

      Source sequence(s)
      AC010531, AC092720, AC105429
      Consensus CDS
      CCDS10961.2
      UniProtKB/TrEMBL
      A0A590UJW6, A0A5F9XIK1
      Related
      ENSP00000499622.1, ENST00000671377.2
      Conserved Domains (3) summary
      cd09558
      Location:431495
      SAM_ZCCH14; SAM domain of ZCCH14 subfamily
      pfam00098
      Location:10451060
      zf-CCHC; Zinc knuckle
      cl02563
      Location:256339
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      87406248..87493024 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005255858.4XP_005255915.3  zinc finger CCHC domain-containing protein 14 isoform X1

      UniProtKB/TrEMBL
      A0A5F9XIK1
    2. XM_017023082.3XP_016878571.1  zinc finger CCHC domain-containing protein 14 isoform X2

      UniProtKB/TrEMBL
      H3BS18
      Related
      ENSP00000456499.1, ENST00000561928.1

    RNA

    1. XR_243401.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      93477129..93563941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379872.1XP_054235847.1  zinc finger CCHC domain-containing protein 14 isoform X1

      UniProtKB/TrEMBL
      A0A5F9XIK1
    2. XM_054379873.1XP_054235848.1  zinc finger CCHC domain-containing protein 14 isoform X2

      UniProtKB/TrEMBL
      H3BS18

    RNA

    1. XR_008489065.1 RNA Sequence